Anubha Bajaj*

Department of Histopathology, Panjab University/A.B. Diagnostics, India

*Corresponding Author: Anubha Bajaj, Department of Histopathology, Panjab University/A.B. Diagnostics, India.

Received: June 22, 2022; Published: July 01, 2022

Abstract

Tubular adenoma is denominated as a neoplastic polyp associated with low grade epithelial dysplasia. Preponderantly emerging within colon, tubular adenoma may configure as a precursor to invasive adenocarcinoma of colorectal region. Singular tubular adenoma is characteristically associated with an estimated < 25% villous component. Tumefaction may be incidentally discerned upon colonoscopy [1,2]. Enhanced consumption of fruits, dietary fibre or folate decimates proportionate metamorphosis of tubular adenoma or possible emergence of conventional colorectal adenoma [1,2]. Tubular adenoma is commonly encountered in individuals >50 years wherein disease incidence is enhanced in elderly individuals. A male predominance is observed. Generally, lesions are common within left colon comprising of left half of transverse colon, splenic flexure, descending colon and sigmoid colon along with rectum [1,2]. Tubular adenoma exhibits a distinctive spectrum of metamorphosis from adenoma to carcinoma comprised of genetic mutations within KRAS, TP53 and APC genes besides β-catenin. Genetic mutations of KRAS appear preponderant in tubular adenomas [1,2].

References

1. Taherian M., et al. “Tubular Adenoma”. Stat Pearls International, Treasure Island, Florida (2022).
2. Myers DJ and Arora K. “Villous Adenoma”. Stat Pearls International. Treasure Island, Florida (2021).
3. Imperiale TF., et al. “Prevalence of Advanced, Precancerous Colorectal Neoplasms in Black and White Populations: A Systematic Review and Meta-analysis”. Gastroenterology 6 (2018): 1776-1786 e1.
4. David Y., et al. “Confounders in Adenoma Detection at Initial Screening Colonoscopy: A Factor in the Assessment of Racial Disparities as a Risk for Colon Cancer”. Journal of Cancer Research and Therapeutics 4 (2019): 269-289.
5. Image 1 Courtesy: Webpathology.com.
6. Image 2 Courtesy: Research gate.

Citation

Citation: Anubha Bajaj. “The Cannulated Amalgamation-Tubular Adenoma". Acta Scientific Gastrointestinal Disorders 5.8 (2022): 01-02.

Copyright

Copyright: © 2022 Anubha Bajaj. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.