Antidiabetic Drugs: Their Hepatoprotective and Hepatocarcinogenic Effect
Mona A Amin*
Internal Medicine, Hepatogastroenterology, Cairo University, Egypt
*Corresponding Author: Mona A Amin, 1Internal Medicine, Hepatogastroenterology, Cairo University, Egypt.
May 24, 2022; Published: June 21, 2022
Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Diabetes mellitus (DM), with insulin resistance, is an established independent risk factor for HCC, as reported in multiple observational studies and subsequent meta-analyses.
Current evidence suggests that there may be interplay between obesity, DM, and tumorigenesis, with insulin resistance and hyperinsulinemia playing critical roles.
Given the significant link of DM with the risk of HCC, the use of antidiabetic medications may modify DM and reduce the risk of cancer as shown in recent research. So, the aim of this review is to illustrate the hepatocarcinogenic and hepatoprotective effects of antidiabetic medications on HCC.
Keywords: Antidiabetic Drugs; Hepatoprotective; Hepatocarcinogenic
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