Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 5 Issue 6

Intestinal Tuberculosis in a Patient with Cushing’s Syndrome: A Case Report

Johanne Myrrh E Soriano, Rene A Amadore*, Roy Raoul H Felipe and Lovell B Gatchalian

Department of Internal Medicine, East Avenue Medical Center, Philippines

*Corresponding Author: Rene A Amadore, Department of Internal Medicine, East Avenue Medical Center, Philippines.

Received: May 05, 2022; Published: May 27, 2022


A 39-year-old woman presented with cushingoid features was worked up and diagnosed to have ACTH-independent Cushing’s syndrome. Computed tomography of the whole abdomen revealed a left adrenal mass. She was scheduled for elective laparoscopic left adrenalectomy; however, a few days prior to the procedure, the patient had hematochezia and was admitted earlier than scheduled. Colonoscopy revealed multiple ulcers on the terminal ileum, to which biopsy and gen expert revealed Mycobacterium tuberculosis infection. The patient underwent laparoscopic left adrenalectomy on the same admission, which revealed adrenal adenoma on histopathology.

Keywords: Cushing’s Syndrome; Mycobacterium Tuberculosis Infection; Adrenal Adenoma; Hematochezia


  1. Flores GP., et al. “The social determinants of tuberculosis in the Philippines”. The Lancet Global Health1 (2022): e38.
  2. Brati M., et al. “Tuberculosis among Health Care Workers (2019).
  3. Jameson JL., et al. “Harrison’s Principles of Internal Medicine. 20th edition”. McGraw Hill (2018).
  4. Li B., et al. “Giant non-functional adrenal adenoma: A case report”. Oncology Letters1 (2012): 378-380.
  5. Chakinala RC and Khatri AM. “Gastrointestinal Tuberculosis” (2020).
  6. Rathi P and Gambhire P. “Abdominal Tuberculosis”. Journal of the Association of Physicians of India 2 (2016): 38-47.
  7. Kasulke RJ., et al. “Primary Tuberculous Enterocolitisrome”. Archives of Surgery1 (1981): 110.
  8. Narasimhan P., et al. “Risk Factors for Tuberculosis”. Pulmonary Medicine (2013): 1-11.
  9. Machuca I., et al. “Tuberculosis in immunosuppressed patients”. Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)6 (2018): 366-374.
  10. Jick SS., et al. “Glucocorticoid use, other associated factors, and the risk of tuberculosis”. Arthritis and Rheumatism1 (2006): 19-26.
  11. Machuca I., et al. “Tuberculosis in immunosuppressed patients”. Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)6 (2018): 366-374.
  12. Xie Y., et al. “Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated with a Reduced Phagocytic Capacity of Macrophages”. Frontiers in Immunology (2021): 12.
  13. Wang J., et al. “Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages”.    Scientific Reports1 (2017).
  14. Graham BS and Tucker WS. “Opportunistic infections in endogenous Cushing’s syndrome”. Annals of Internal Medicine3 (1984): 334-338.
  15. Juszczak A. “Cushing’s Syndrome” (2021).
  16. Scheinman RI., et al. “Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids”. Science5234 (1995): 283-286.
  17. Bakker RC., et al. “Cushing’s syndrome complicated by multiple opportunistic infections”. Journal of Endocrinological Investigation 21 (1998): 329-333.
  18. Kapoor VK. “Abdominal tuberculosis”. Postgraduate Medical Journal874 (1998): 459-467.


Citation: Rene A Amadore., et al. “Intestinal Tuberculosis in a Patient with Cushing’s Syndrome: A Case Report". Acta Scientific Gastrointestinal Disorders 5.6 (2022): 67-70.


Copyright: © 2022 Rene A Amadore., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US