Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 5 Issue 6

Transarterial Chemoembolization in the Treatment of Gastric Cancer with Liver Metastases

Arybzhanov DT1*, Gantsev SHKH2 and Rysbekov MM2

1Federal State Budgetary Educational Institution of Further Professional Education “Bashkir State Medical University”, Ufa, Bashkortostan, Russia
2“South -Kazakhstan Medical Academy” JSC, Shymkent City Cancer Center, Shymkent, Kazakhstan

*Corresponding Author: Arybzhanov DT, Federal State Budgetary Educational Institution of Further Professional Education “Bashkir State Medical University”, Ufa, Bashkortostan, Russia.

Received: November 01, 2021; Published: May 20, 2022

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Abstract

The treatment of gastric cancer remains an urgent problem in Oncology. One of the unresolved problems in the treatment of gastric cancer remains the patients with liver metastases. With the development of interventional radiology, it became possible to treat gastric cancer patients with liver metastases.

The objective of the Research: Improving the treatment outcomes of gastric cancer patients with liver metastases by using transarterial chemoembolization (TACE).

Materials and Methods: We analyzed the results of 60 patients for the period 2008-2020, who sought medical attention due to metastatic liver disease, previously they received the combination therapy at various times. The average age of patients was 58.1 ± 5.8 years. When planning TACE, the general condition of all patients was over 80% according to Karnofsky Performance Status, according to ECOG 1-2. All patients underwent TACE of metastatic foci of the liver with the use of Lipiodol (6-8 ml) + Doxorubicinum (25 mg/m2). The interval between TACE cycles was 1.5-2 months. Each patient underwent 5-6 courses of TACE.

The Outcomes and its Discussion: Immediate results showed the treatment efficacy after 2 courses of TACE in 49 (81.7%) patients: partial regression - 36 (60%) patients, significant regression - 13 (21.6%) patients, stabilization of the process - 11 (18.3%) patients. The case follow -up showed the following results: 37 (61.7%) patients lived for 6 months, 24 (40%) patients lived for 12 months, 11 (18.3%) patients lived for 18 months, 8 (13.3%) patients lived for 24 months, and only 3 (5.0%) patients lived for 36 months. Median survival was 15.5 ± 1.2 months.

Conclusions: The immediate and long-term results of the research, performing TACE in gastric cancer patients with metastases was effective in 50% of cases. The case follow -up for 3 years showed that 37 (61.7%) patients lived for 6 months, 24 (40%) patients lived for 12 months, 11 (18.3%) patients lived for 18 months, 8 (13.3%) patients lived for 24 months, and only 3 (5.0%) patients lived for 36 months. At the same time, the median survival was 15.5 ± 1.2 months.

Currently, to improve the survival and quality of life of gastric cancer patients with metastases, the technique of transarterial chemoembolization can be considered as an effective, low-toxic method of treatment and it can be the method of choice.

 

Keywords: Chemoembolization; Gastric Cancer; Liver Metastases

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References

  1. Mastoraki A., et al. "The role of surgery in the therapeuticapproach of gastric cancer liver metastases”. Indian Journal of Gastroenterology 5 (2016): 331-336.
  2. Kaydarova DR. “Indicators of cancer care of the Republic of Kazakhstan for 2019 (statistics and analysis)”. Almaty (2020): 137.
  3. Kaprin AD. “Malignant neoplasms in Russia in 2016 (morbidity and mortality)/Kaprin A.D., Starinskiy VV and Petrova GVM. “Federal State Budgetary Institution “Moscow Scientific and Research Oncological Institute named after Gertsen P.A.” of the Ministry of Health of the Russian Federation (2018): 250
  4. Zhang K and Chen L. “Chinese consensus on the diagnosis and treatment of gastric cancer with liver metastases”. Therapeutic Advances in Medical Oncology 12 (2020): 1758835920904803.
  5. Granov AM. “Interventional radiology in Oncology (development and technology)/ SPb: - Foliant (2007): 88-97.
  6. Gantsev SHKH., et al. “The chemotherapy method of gastric cancer liver metastases”. Patent of the Russian Federation (2009):
  7. Chen H., et al. “Comparison of Safety and Efficacy of Different Models of Target Vessel Regional Chemotherapy for Gastric Cancer with Liver Metastases”. Chemotherapy2 (2016): 99-107.
  8. Chen H., et al. “Target hepatic artery regional chemotherapy and bevacizumab perfusion in liver metastatic colorectal cancer after failure of first-line or second-line systemic chemotherapy”. Anticancer Drugs2 (2016): 118-126.
  9. Sawatsubashi T., et al. “A Case of Metachronous Multiple LiverMetastases of AFP and PIVKA-Producing Gastric Cancer, Responding to Transcatheter Arterial Chemoembolization”. Gan To Kagaku Ryoho2 (2020): 319-321.
  10. Liu SF., et al. “Comparison of Therapeutic Efficacy between Gastrectomy with Transarterial Chemoembolization Plus Systemic Chemotherapy and Systemic Chemotherapy Alone in GastricCancer with Synchronous Liver Metastasis”. Chinese Medical Journal 16 (2015): 2194-201.
  11. Xu H., et al. “Comparative Study of Drug-eluting Beads versus Conventional Transarterial Chemoembolization for Treating Peculiar Anatomical Sites of GastricCancer Liver Metastasis”. Medical Science Monitor 26 (2020): e922988.
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Citation

Citation: Arybzhanov DT., et al. “Transarterial Chemoembolization in the Treatment of Gastric Cancer with Liver Metastases". Acta Scientific Gastrointestinal Disorders 5.6 (2022): 51-54.




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