Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 5 Issue 6

Severe Acute Hepatitis Associated with Hemolytic Anemia: Rare Manifestations of EBV infection: Case Report

Houda El Moufid1*, Kenza Kissi1, Ahmed Sqalli Houssini1, Abderrazzak Ajertil1, Kaoutar Znati2 and Mohammed Mohammadi1

1Department of Hepato-Gastroenterology, Cheikh Zayd International University Hospital, UIASS, Rabat, Morocco
2Department of Anatomopathology, Cheikh Zayd International University Hospital, UIASS, Rabat, Morocco

*Corresponding Author: Houda El Moufid, Department of Hepato-Gastroenterology, Cheikh Zayd International University Hospital, UIASS, Rabat, Morocco.

Received: April 25, 2022; Published: May 18, 2022

Abstract

Introduction: Epstein Barr virus (EBV) infection is widespread with more than 90% of sero-positive adults worldwide.

Case Report: A 28-year-old young woman was admitted for acute hepatitis with jaundice secondary to hemolytic anemia. The biological results were compatible with severe acute viral hepatitis associated with autoimmune hemolytic anemia. The diagnosis of acute EBV infection was confirmed by serological markers, and indirect histological signs of viral infection on liver biopsy.

Conclusion: Although common, liver damage is generally mild with transient increase of serum transaminases, cases of severe hepatitis as well as autoimmune hemolytic anemia are rare. We report this case to draw attention to the unexpected severity of liver damage from this virus.

Keywords: Epstein Barr Virus; Hepatitis; Mononucleosis Infection; Autoimmune Hemolytic Anemia

References

  1. Lalazar G and Ilan Y. “Viral Diseases of the Liver”. In: Gershwin ME, Vierling JM, Manns MP, eds. Liver Immunology. Springer International Publishing (2014): 159-171.
  2. Mellinger JL., et al. “Epstein-Barr Virus (EBV) Related Acute Liver Failure: A Case Series from the US Acute Liver Failure Study Group”. Digestive Diseases and Sciences 7 (2014): 1630-1637.
  3. Markin RS. “Manifestations of Epstein-Barr virus-associated disorders in liver”. Liver1 (2008): 1-13.
  4. Kondo T., et al. “Essential roles of the Fas ligand in the development of hepatitis”. Nature Medicine 4 (1997): 409-413.
  5. Kofteridis DP., et al. “Epstein Barr virus hepatitis”. European Journal of Internal Medicine 1 (2011): 73-76.
  6. Salama A, Ahrens N, Kiesewetter H. Serological and Clinical Aspects of Autoimmune Hemolytic Anemias”. Transfusion Medicine and Hemotherapy 4 (2002): 206-217.
  7. Berentsen S and Tjønnfjord GE. “Diagnosis and treatment of cold agglutinin mediated autoimmune hemolytic anemia”. Blood Reviews 3 (2012): 107-115.
  8. Baudet Arteaga JS., et al. “Intense icterus in the course of EBV infectious mononucleosis”. Revista Espanola de Enfermedades Digestivas: Organo Oficial De La Sociedad Espanola de Patologia Digestiva 10 (1996): 709-711.
  9. Arai A., et al. “Autoimmune hemolytic anemia accompanied by reactivation of an Epstein-Barr virus infection with suppressed CTL response to EBV-infected cells in an elderly man”. Internal Medicine (Tokyo, Japan) 4 (2010): 325-329.
  10. Clinical manifestations and treatment of Epstein-Barr virus infection - UpToDate (2022).
  11. De Paor M., et al. “Antiviral agents for infectious mononucleosis (glandular fever)”. Cochrane Database of Systematic Reviews 12 (2016): CD011487.

Citation

Citation: Houda El Moufid., et al. “Severe Acute Hepatitis Associated with Hemolytic Anemia: Rare Manifestations of EBV infection: Case Report". Acta Scientific Gastrointestinal Disorders 5.6 (2022): 12-15.

Copyright

Copyright: © 2022 Houda El Moufid., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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