Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 5 Issue 6

Influence of Carbohydrate Metabolism Compensation on the Heart Failure Development in Patients with Arterial Hypertension and Obesity

OM Bilovol1, II Knyazkova1, IP Dunaіeva1 and NA Kravchun2*

1Kharkiv National Medical University of the Ministry of Health of Ukraine, Kharkiv, Ukraine
2Multidisciplinary Medical Center “Life Park”, Kharkiv, Ukraine

*Corresponding Author: NA Kravchun, Multidisciplinary Medical Center “Life Park”, Kharkiv, Ukraine.

Received: April 06, 2022; Published: May 18, 2022


Background: Arterial hypertension, especially in combination with diabetes mellitus, which significantly increases the risk of micro- and macrovascular complications, with hypercholesterinemia, coronary artery disease, congestive heart failure, is the main risk factor for the premature development of atherosclerosis, which generally leads to the development of severe long-term cardiovascular adverse effects. The aim of this study was to determine the state of carbohydrate metabolism compensation and its possible impact on the development of congestive heart failure, its progression in patients with hypertension and obesity.

Materials and Methods: A comprehensive examination of 34 patients with arterial hypertension and obesity and type II diabetes mellitus, 32 patients with AH and type II DM, 36 patients with AH and obesity, and 30 patients with AH has been carried out. The Control group consisted of 20 healthy individuals without arterial hypertension and carbohydrate metabolism disorders.

Results: The examined groups of patients did not differ significantly in age, gender, history of myocardial infarction. In the Control group, the subjects were younger and did not suffer from hypertension, type 2 diabetes mellitus, and obesity. At the same time, very pronounced changes in carbohydrate metabolism in patients with different variants of comorbid pathology have been identified. Comparative analysis of carbohydrate metabolism in the studied groups of patients showed that comorbidity of hypertension, type 2 diabetes mellitus, and obesity leads to significant shifts. Metabolic disorders in type 2 diabetes mellitus have been shown to lead to impaired energy metabolism in cardiomyocytes due to insulin resistance.

Conclusions: The study demonstrates that arterial hypertension, type 2 diabetes mellitus, obesity, hyperinsulinemia, and insulin resistance have a general pathogenetic effect on its progression in patients with cardiovascular pathology, lead to the summation and potentiation of cardiovascular risk.

Keywords: Arterial Hypertension; Type 2 Diabetes Mellitus; Obesity; Congestive Heart Failure


  1. Chichareon P., et al. Atherosclerosis 295 (2020): 45-53.
  2. Bancks MP., et al. Diabetes Care3 (2019): 457-465.
  3. Mak K-H., et al. European Journal of Preventive Cardiology (2021): zwab011.
  4. Gholap NN., et al. Diabetes, Obesity and Metabolism 3 (2017): 364-374.
  5. Серік СА., et al. Problems of Endocrine Pathology 78.4 (2021): 57-64.
  6. Gorb YuG., et al. UZHMS 4.1 (2019): 8-20.
  7. Dal Canto E., et al. European Journal of Preventive Cardiology 2 (2019): 25-32.
  8. Thomas MC. Current Cardiology Reviews 3 (2016): 249-255.
  9. Arnett DK., et al. Journal of the American College of Cardiology 10 (2019): 1376-1414.
  10. Li S, Nemeth I, Donnelly L, et al. Diabetes Care2 (2020): 426-432.
  11. Ormazabal V., et al. Cardiovascular Diabetology1 (2018): 122.
  12. Zhou D., et al. Scientific Reports1 (2018): 9418.
  13. Pashentseva AV., et al. Obesity and Metabolism2 (2017): 9-17.
  14. Sokolova LA., et al. Hypertense 2017; 23.4 (2017): 294-302.
  15. Hill MA., et al. Metabolism 119 (2021): 154766.


Citation: NA Kravchun., et al. “Influence of Carbohydrate Metabolism Compensation on the Heart Failure Development in Patients with Arterial Hypertension and Obesity". Acta Scientific Gastrointestinal Disorders 5.6 (2022): 03-07.


Copyright: © 2022 NA Kravchun., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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