Department of Internal Medicine, Widya Mandala Catholic University Surabaya, Panti Nirmala Hospital Malang, Indonesia
*Corresponding Author: Winarko Luminturahardjo, Department of Internal Medicine, Widya Mandala Catholic University Surabaya, Panti Nirmala Hospital Malang, Indonesia.
Received: March 31, 2022; Published: April 27, 2022
COVID-19 infection has become a global pandemic and has hit almost all countries in the world. SARS CoV2 virus can cause mainly respiratory infection called COVID19, but can also influence another organs, like gastrointestinal system. One of the comorbidities related to the digestive organs is Inflammatory Bowel Disease (IBD) which is the most common inflammation in the large intestine. The prevalence rate of IBD has recently increased (approximately 400 cases per 100,000 person/years in 2020) mainly related to low fiber diet, smoking, alcohol consumption, obesity and the influence of environmental factors, such as air pollution. The mechanism of the relationship between COVID19 infection and IBD is still not widely known. Several theories explain that genetic factors, direct infection with the SARS-CoV2 virus, inflammation, the influence of the gut microbiota, and COVID19 therapy are suspected of having effect on the worsening of IBD. Through this article, the author would like to describe some of the pathomechanism reviews of the influence of COVID19 infection on patients who have experienced IBD. By knowing the right pathomechanism, it is hoped that medical personnel can handle cases of patients with IBD who experience COVID-19 infection and can further reduce the morbidity and mortality rates.
Keywords:COVID19; IBD; Direct Infection; Inflammation; Dysbiosis; Hypercoagulation
Citation: Winarko Luminturahardjo. “COVID-19 and Gastrointestinal Disorders: Possible Pathomechanism of SARS-CoV2 Infection in Inflammatory Bowel Disease Patients". Acta Scientific Gastrointestinal Disorders 5.5 (2022): 58-64.
Copyright: © 2022 Winarko Luminturahardjo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.