Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Mini Review Volume 5 Issue 4

Pharmacotherapy of Gastroesophageal Reflux Disease in Children

Suraj Gupte1*, Novy Gupte2 and Sushmita Patil3

1Professor and Head (Emeritus), Postgraduate Department of Pediatrics, MMC and Hospitals, Khammam, India
2Assistant Professor, Department of Pharmacology, Army College of Medical Sciences, New Delhi, India
3Consulting Pediatrician, Wadia Hospital, Mumbai, India

*Corresponding Author: Suraj Gupte, Professor and Head (Emeritus), Postgraduate Department of Pediatrics, MMC and Hospitals, Khammam, India.

Received: March 07, 2022; Published: March 14, 2022


Background: Gastroesophageal reflux disease (GERD), once a domain of adults only, is now being frequently diagnosed beyond first year of life. However, therapeutic approach to its pharmacological management remains debatable.

Objective: Putting into perspectives the current concepts with our own observations in the drug therapy of GERD in pediatric practice.

Design: Review of recent English medical literature with authors’ own experience in the field.

Salient Features: High index of suspicion followed by a therapeutic trial employing an anti-reflux should precede diagnostic test(s) as and when indicated. H2 receptor antagonists, preferably ranitidine, should be the drug of first choice in children. A prokintic, preferably metoclopramide, is helpful in cases where abdominal distention and bloating are predominant. The more potent H2 receptor antagonist, cisapride as also the proton pump inhibitors should be reserved for difficult cases not responding to aforesaid approach.

Conclusions: First line treatment of pediatric GERD largely revolves around ranitidine, a H2 antagonist. Metoclopramide, a prokinetic, is helpful as an add-on in case of predominant bloating and abdominal distention. Proton pump inhibitors are now picking up as the preferred choice.

Keywords: Gastroesophageal Reflux Disease (GERD); H2 Receptor Antagonists; Metaclopramide; Omeprazole; Pantaprozole; Prokinetics; Proton-Pump Inhibitors (PPIs); Ranitidine


  1. Patwari A., et al. “Gastroenterology". In: Gupte S (edition): The Short Textbook of Pediatrics, 13th New Delhi: Jaypee (2020): 467-504.
  2. American Academy of Otolaryngology, Head and Neck Surgery. “Pediatric GERD: (Gastroesophageal reflux disease)”.
  3. Ruigómez A., et al. “Gastroesophageal reflux disease in children and adolescents in primary care”. Scandinavian Journal of Gastroenterology 45 (2010): 139-146.
  4. Kale P and Tiwari S. “Gastroesophageal reflux disease”. In: Gupte S (Ed): Recent Advances in Pediatrics (Specal Vol 23: Pediatric Gastroenterology, Hepatology and Nutrition). New Delhi: Jaypee (2013).
  5. Gupte S. “Guest lecture: GERD in children: Two decades’ experience in therapeutics”. Asian-Oceanian Workshop on Pediatric Gastroenterology, Hepatology and Nutrition, Bangkok (2019).
  6. Mohan N., et al. “Pediatric Gastroenterology Chapter of Indian Academy of Pediatrics, Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition)”. Indian Pediatrics 28 (2022): 202-228.
  7. Gupte S. “Expert Opinion: Pharmacotherapy of Pediatric GERD”. In: GERD Dialogue. New Delhi: Health Knowledge Source (2018).
  8. Gupte S and Gupte N. “Pediatric Drug Directory”. 9th New Delhi: Jaypee (2020).


Citation: Suraj Gupte., et al. “Pharmacotherapy of Gastroesophageal Reflux Disease in Children". Acta Scientific Gastrointestinal Disorders 5.4 (2022): 31-34.


Copyright: © 2022 Suraj Gupte., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US