K El Montacer1*, W Hliwa1, Ri Seydou1, F Haddad1, FZ El Rhaoussi1, M Tahiri1, A Bellabah1, W Badre1 and M Regragui2
1Hepato-Gastroenterology Department of the University Hospital Center IBN ROCHD of Casablanca, Morocco
2Anatomopathology Department of the University Hospital Center IBN ROCHD of Casablanca, Morocco
*Corresponding Author: K El Montacer, Hepato-Gastroenterology Department of the University Hospital Center IBN ROCHD of Casablanca, Morocco.
Received: November 10, 2021; Published: March 04, 2022
Background: Renal failure secondary to AA amyloidosis is a common cause of death among patients with untreated Crohn's disease. Once amyloid deposits set in, they are irreversible; however, controlling the inflammation limits the progression of tissue damage and stabilizes the disease.
Aim of the study: To describe the case of Crohn's disease with a delayed diagnosis reaching complication stage: renal and vascular amyloidosis with a poor prognosis, in order to make practitioners aware of the importance of systematic screening for this severe complication and the establishment as soon as possible of a specific therapeutic strategy aimed at controlling inflammation and slowing progression to end-stage chronic renal disease.
Case report: A 50years old male patient diagnosed, simultaneously, after 20 years of symptom progression, with stenosing ileocolic Crohn's disease complicated by systemic AA amyloidosis revealed by renal failure and episodes of vasoplegia. Ileo-caecal resection and control of inflammation with steroids and immunosuppressive therapy resulted in stabilization of renal status and decreased frequency of orthostatic hypotension episodes.
Conclusion: Screening for proteinuria and impaired renal function in patients with chronic inflammatory diseases, particularly Crohn's disease, allows early diagnosis of secondary amyloidosis. Although no treatment has been proven effective for the reversibility of amyloid deposits; control of inflammation seems to stop amyloidogenesis and consequently limits the progression of organ dysfunction.
Keywords: Crohn's Disease; Arterial Hypotension; AA Amyloidosis; Immunosuppressant
Citation: K El Montacer., et al. “Amyloid Vasculopathy Revealed by Episodes of Severe Arterial Hypotension Complicating Crohn's Disease". Acta Scientific Gastrointestinal Disorders 5.4 (2022): 03-06.
Copyright: © 2022 K El Montacer., et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.