ATR Mediated Activity of Molecular Editors on Oncological Cells
Miss Akanksha Singh*
Dr Ambedkar College, Deeksha Bhoomi, Nagpur, Maharashtra, India
*Corresponding Author: Miss Akanksha Singh, Dr Ambedkar College, Deeksha Bhoomi, Nagpur, Maharashtra, India.
December 14, 2021; Published: February 25, 2022
CRISPR Cas 9, a biologist editing guide has conquered molecular genetics with its supreme ability to edit the human genome thus eradicating the complexity involved in proteomics and recombinant DNA technology to cure many genetic diseases. In this study, the CRISPR Cas 9 machinery has been applied to demonstrate anti tumoral activity with the aid of molecular sensors working in the DNA replication like ATR that, at times of normal replication allows the stalled replication forks to move further that will eliminate circumstances leading to apoptosis. This biomolecule is used as anti- cancer tool to prevent detrimental effects of malignancies associated with the cancer. During the progression S-phase, most of the times, the cell accurately completes the replication but when cell senses the mutation or any physical damage in its way of replicating DNA, the replication machinery gets halted thus accumulating many ssDNA molecules and this stimulates ATR molecule to bind and pave the way for completion of replication. This review juxtaposed the anticancer effects in mammalian and mouse cells and indicated ATR to be important molecule in diagnosis of cancer.
Keywords: CRISPR Cas 9; Proteomics; Molecular Sensors; ATR; Apoptosis; Malignancies
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