2004 Study of Risk Factors for an Increasing Gradient in the Burden of
Liver Cirrhosis in 158 Countries in Men and Women
Ludmila Alexandrovna Radkevich* and Dariya Andreyevna Radkevich
Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences, Moscow, Russia
*Corresponding Author: Ludmila Alexandrovna Radkevich, Center for Theoretical Problems of Physicochemical Pharmacology of the Russian Academy of Sciences, Moscow, Russia.
January 21, 2022; Published: February 21, 2022
Goals and objectives of this study: To conduct a step-by-step comparative analysis of the risk factors for the formation of the cirrhosis burden gradient in 8 groups of 158 countries of the world. 2004.
Conduct a stepwise comparative analysis of risk factors for the formation of a gradient in the burden of cirrhosis of the liver (LC) in 8 groups of 158 countries.
Materials and Methods: A comparative analysis of risk factors for the burden of liver cirrhosis (LC) in 2004 (GBD, 2004) was performed using the Mann- Whitney U test in 8 groups of countries of the world, 20 countries in each group.
Results: In accordance with the goal in our research, it was found that in countries 1- group 8 compared with group 8 countries, the median burden of liver cirrhosis was 10 times higher (p ≤ 0.001). Burden of comorbid diseases - alcoholism and cardiovascular disease were 2 times higher in the 8th group of countries compared to the 1st group of countries (p ≤ 0. 001).
The burden of diabetes did not differ statistically significantly between the countries of the 1st and 2nd th groups. Per capita income dropped sharply by 10 times from group 1 to groups 3-4. Further from the 4th group, per capita income increased by 4-6 times to the 8th group of countries. Ultraviolet (J/n2) increased to the equator from 1 to 4 groups of countries, and then decreased towards northern latitudes. The longitude grew from Group 1 to Group 8 (from 30° to 70°).
Quality of life indicators in the 8 country groups were statistically dependent on income IPC. General level of food consumption the overall level of consumption of TCL products did not change significantly between country groups and tended to decrease. The total percentage of consumption of alcoholic drinks (strong alcohol, wine and beer - g/person/day) from of the total level of food consumption TCL, a statistically significant decrease from group 1 to group 8 of countries. The ratio of the level of consumption of strong alcohol to wine, or beer, increased statistically significantly from the 1st group of countries to the 8th group by 2-3 times. The ratio of animal fat to vegetable oils increased from Group 1 to Group 8 countries. Total energy and total fat (kcal/person/day) decreased from Group 1 to Group8 9 countries with unchanged protein levels. However, the % of animal fat of total fat steadily increased significantly in the direction of the increasing LC gradient from country group 1 to country group 8. From the 1st group of countries to the 8th group, the percentage of fast NAT2 acetylators increased.
Conclusion: The results obtained suggest a two-phase change in economic and geographical characteristics. An increase in the consumption of strong alcohol and animal fat with a stepwise cross-country growth of the cirrhosis LC gradient. Further research into risk factors for cirrhosis LC is needed.
Keywords: Liver Cirrhosis Burden Gradient in 158 Countries; Cardiovascular Vascular Disease; Diabetes Mellitus; Alcoholism; Risk Factors; Levels of Alcohol and Food Consumption; Metabolic Syndrome
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