Ahmet Özer Şehirli*
Near East University, Faculty of Dentistry, Department of Pharmacology, Turkey
*Corresponding Author: Ahmet Özer Şehirli, Near East University, Faculty of Dentistry, Department of Pharmacology, Turkey.
Received: January 17, 2022; Published: February 01, 2022
The potential for side effects is the most important factor limiting the treatment in treatments performed during cancer, which is one of the most important problems of recent times . Some of the agents used in this treatment are also used in the treatment of autoimmune diseases due to their immunosuppressive properties. One of the side effects of these agents is the damage they cause in the gastrointestinal tract, which is manifested by symptoms of nausea-vomiting, diarrhea/constipation . It is a condition that occurs as a result of the agents used during chemotherapy affect not only the tumor cell but also healthy cells. Free oxygen radicals, as well as neurotransmitters and hormones such as dopamine, serotonin, histamine, norepinephrine, vasoactive intestinal peptide, gastrin, vasopressin, thyrotropine-releasing hormone, leucine-enkephalin and substance-P, in the damage in the gastrointestinal tract, increase in inflammatory cytokine levels, decrease in endogenous anti-inflammatory and antioxidant enzyme activations play an important role [2-4] Therefore, although the studies carried out to correct this situation are increasing day by day, it still continues to be a problem as a clinic. For this purpose, studies with anti-inflammatory and immunomodulatory drugs with antioxidant properties have accelerated, and the development of nanoparticles that only selectively affect tumor cells has been accelerated [5,6].
Citation: Ahmet Özer Şehirli. “Effects of Drugs Used in Cancer Treatment on The Gastrointestinal Tract". Acta Scientific Gastrointestinal Disorders 5.3 (2022): 01.
Copyright: © 2022 Ahmet Özer Şehirli. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.