Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 5 Issue 2

Role of Adrenoreceptors in the Implementation of the Stimulator Effect of Serotonin on WPC

DS Sveshnikovv1, MR Smirnov2* and AV Kuchuk3

1Doctor of Medical Sciences, Associate Professor of the Department of Physiology, Peoples' Friendship University of Russia (RUDN), Moscow, Russia

2Doctor of Biological Sciences, Professor of the Department of Physiology of the Russian National Research Medical University Named After V.M. N.I. Pirogov (RNIMU), Moscow, Russia

3Candidate of Medical Sciences, Assistant of the Department of Anatomy of the RUDN University, Moscow, Russia

*Corresponding Author: MR Smirnov, Doctor of Biological Sciences, Professor of the Department of Physiology of the Russian National Research Medical University Named After V.M. N.I. Pirogov (RNIMU), Moscow, Russia.

Received: October 04, 2021; Published: January 31, 2022


We have established that b-adrenergic receptors prevent the development of a stimulatory effect in response to the introduction of serotonin into the body. This action of b-adrenergic receptors is very strong - when serotonin is introduced into the body under conditions of blockade of b-adrenergic receptors, the stimulatory effect of dpk is 5 times greater than in infarcted animals. This is due to the fact that the serotonin introduced into the body activates not only 5HT receptors of serotonergic neurons and smooth muscles, but also presynaptic 5 - HT receptors of sympathetic nerve endings. Their activation leads to the release of norepinephrine, the latter inhibits contractions of the smooth muscles of the intestine. But the stimulating effect of serotonin on smooth muscle is stronger than the inhibitory effect of norepinephrine.

Keywords: Duodenum; Motility; Serotonin Adipate; Α- and Β-Adrenergic Receptors


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Citation: MR Smirnov., et al. “Role of Adrenoreceptors in the Implementation of the Stimulator Effect of Serotonin on WPC". Acta Scientific Gastrointestinal Disorders 5.2 (2022): 56-60.


Copyright: © 2022 MR Smirnov., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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