Evrim Suna Arikan Söylemez¹*, Dağıstan Tolga Arıöz², Müjgan Özdemir Erdoğan³, Fatih Çelik² and Mariam Chkhikvadze²

¹Department of Medical Biology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey

³Department of Medical Genetic, Faculty of Medicine, Afyonkarahisar Health Sciences University, Turkey

*Corresponding Author: Evrim Suna Arikan Söylemez, Department of Medical Biology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Received: January 17, 2022; Published: January 24, 2022

Abstract

Preeclampsia (PE), one of the most serious complications of pregnancy, is characterized by endothelial dysfunction and hypertension. Gastrointestinal complications of preeclampsia can occur and have the risk of being life-threatening for the mother and fetus. Genetic predisposition is a risk factor for PE. In this context, the genotype rates and allele frequencies of the STOX1 gene rs1341667 (Y153H) polymorphism in peripheral blood and placental tissues (decidua, umblical cord) of 25 PE patients and 25 healthy controls were examined by Light Cycler^® Nano Real Time PCR Instrument (Roche Applied Systems). The STOX1 gene rs1341667 polymorphism exists in three different genotypes in humans: TT (wild type), TC (heterozygous) and CC (mutant). When the genotype frequencies of peripheral blood and placenta samples were compared between patients and controls, there was no difference (P > 0.05). The genotype results of the decidua and umblical cord samples, analyzed from the same placenta in all cases, were the same. There was no difference between allele frequencies of the patients and controls (P > 0.05). In our study, rs1341667 polymorphism was detected in peripheral blood and placental tissues of preeclamptic mothers. However, this polymorphism was also detected in healthy pregnant women peripheral bloods and their placental tissues. There was no difference between the frequencies of the C allele, which is the risk allele, in both blood and placental tissues of controls and PE patients. In this regard, we cannot support the view that the relevant polymorphism predisposes to preeclampsia. However, our study has small number of patients. This polymorphism needs to be analyzed in large populations.

Keywords: Preeclampsia; STOX1; Y153H; rs1341667; Polymorphism

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Citation

Citation: Evrim Suna Arikan Söylemez., et al. “Investigation of the Frequency of STOX1 Y153H Polymophism in Patients with Preeclampsia". Acta Scientific Gastrointestinal Disorders 5.2 (2022): 36-42.

Copyright

Copyright: © 2022 Evrim Suna Arikan Söylemez., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.