Mariem Ben Jemaa¹, Fatma Mhamdi², Hanen Falleh¹, Riadh Ksouri¹ and Raja Serairi Beji^1,3*

¹Laboratorire des Plantes Aromatiques et Médicinales, Centre de Biotechnologie de Borj Cedria, Hammam-lif, Tunisie

³École Supérieure des Sciences et Techniques de la Santé de Tunis. Tunisie

*Corresponding Author: Raja Serairi Beji, Laboratorire des Plantes Aromatiques et Médicinales, Centre de Biotechnologie de Borj Cedria, Hammam-lif, Tunisie.

Received: December 20, 2021; Published: January 24, 2022 January 21, 2022

Abstract

This manuscript was focused on the nutritional behavior of nasopharyngeal carcinoma patients and the assessment of their quantitative and qualitative dietary balance in order to evaluate the role of dietary factors in patient healing process. The first part of the study was devoted to a retrospective cross-sectional survey involving 50 patients diagnosed with nasopharyngeal carcinoma in order to investigate their nutritional behavior. The interview identified the patient gender, age, family situation, ethnicity, career, family and personal ancestors, swallowing difficulties, and the date of diagnosis. After that, the anthropometric profile of questioned patients was drawn via their size, weight and their Body Mass Index (BMI) measurements. In addition, their brachial circumference, their tricipital cutan fold and their brachial muscle circumference were evaluated. Finally, blood samples of investigated patient were used for Albuminemia, Reactive Protein C (RPC), Superoxyde Dismutase (SOD) and for the Glutathion peroxydase measurements. Obtained results demonstrated that the questioned population was formed of 68% men and the average age was 55 years. Moreover, 77,6% of questioned patient declared their new diagnosis and 33 patients had difficulty to swallow. Considering the anthropometric profile of questioned patients, results highlighted that 70% of the studied population had a normal BMI, 26% were in overweight, and just 2% had grade 1 malnutrition. Gathered results suggested that the average of brachial circumference, tricipital cutan fold and muscle circumference were 19,86; 11,63 and 16,23, respectively. Blood biological analysis demonstrated that all the studied sample were in an inflammatory phase, 90% have hypoalbuminemia, 72,4% showed a decrease in the enzymatic activity of the Superoxyde Dismutase and the Glutathion peroxydase. In conclusion, gathered results present an interesting data basis for therapists in order to avoid malnutrition and its consequences for nasopharyngeal carcinoma patients.

Keywords:Nutritional Behavior; Dietary Balance; Nasopharyngeal Carcinoma

References

1. Rebecca Siegel., et al. “Cancer Statistics 64 (2014): 9-29
2. OMS, Communique De Presse N° 263; “Dernières données mondiales sur le cancer: le fardeau du cancer atteint 18,1 million de nouveaux cas et 9,6 million de décès par cancer en 2018” (2018).
3. Ma B and Chan A. “Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma”. Bulletin du Cancer 103 (2005): 22-31.
4. Mathilde Beurrier. “Dietetique et nutrition chez le patient atteint de cancer: importance de la prise en charge et rôle du pharmacien d’officine (2016): 1-81.
5. Ed John. “LE suivi du patient cancéreux” Dialogue ville-hôpital. Formation Médicale Continue
6. “Le stress oxydant: intérêt conceptuel et expérimental dans la Compréhension des mécanismes des maladies et potentiel thérapeutique”. L’actualité Clinique (2003): 108-115.
7. Jean-louisvincent., et al. “Albumin administration in the acutely ill: what is new and where next?” Juillet (2014).
8. Comlan Jules Gninkoun. “Statut Des Marqueurs Du Stress Oxydatif au Service De Medecine Interne Et D'endocrinologie De L'hopital Du Mali” (2019): 45-51.
9. Zhiyingzhang,Suzette l., et al. “Evaluation of blood biomarkers associated with risk of malnutrition in older adults. A Systematic Review and Meta-Analysis” Nutrients 9.8 (2017): 829.
10. Del giudice M and Gangestad SW. “Rethinking IL-6 and CRP: why they are more than inflammatory biomarkers, and why it matters”. Brain, Behavior and Immunity 70 (2018): 61-75
11. Bruno Baudin. “Doser les enzymes du stress oxydant, oui ou non?” Revue Francophone des Laboratoires 522 (2020): 62-65.
12. He L., et al. “Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive oxygen Species”. Cellular Physiology and Biochemistry 2 (2017): 532-553.
13. Medhioub M., et al. “Evaluation de l’état nutritionnel chez les cirrhotiques”. La Revue de Médecine Interne 38 (2017): A142
14. Kouassi K., et al. “Prevalence of protein-energy undernutrition evaluated by the measurement of triceps skinfold thickness and mid-arm muscle circumference of 103 adults with cirrhosis of the liver hospitalized in the department of hepatology and gastroenterology of the Lomé Campus University Hospital (Togo)”. Medecine et sante tropicales2 (2014): 208-213.
15. Calmels P and Woisard V. “Indication de la Rééducation en cancérologie. Fascicule” 4: les déficiences liées aux cancers des voies aéro-digestives supérieures (VADS) (2014).
16. Fondation contre le Cancer”. Alimentation des personnes atteintes de cancer” (2014).
17. S Poirier., et al. “Volatile Nitrosamine Levels and Genotoxicity of Food Samples After Nitrosation from High-Risk Areas for Nasopharyngeal Carcinoma Before And after nitrosation”. International Journal of Cancer 44 (2015): 1088-1094.
18. Stefaan De Sme. “Viande et Cancer: unpoint de vue”. Viandes AND Produits Carnés (2018): 34‐35.
19. Zhenshi Xu., et al. “Cancer mortality attributable to cigarette smoking in 2005, 2010 and 2015 in Qingdao, China”. PLoS One (2018): 1-11.
20. Mark L Dreher. “Whole Fruits and Fruit Fiber Emerging Health Effects”. Nutrient 12 (2018): 1833.
21. M Pressoir., et al. “Prevalence, risk factors and clinical implications of malnutrition in French Comprehensive Cancer Centres”. British Journal of Cancer 102 (2010): 966-971.
22. Righini C., et al. “Évaluation du statut nutritionnel, lors du diagnostic, des patients traités pour un cancer des voies aérodigestives supérieures (VADS)”. Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale1 (2013): 8-14.
23. Righini CA., et al. “Assessment of nutritional status at the time of diagnosis in patients treated for head and neck cancer”. European Annals of Otorhinolaryngology, Head and Neck Diseases1 (2013): 8-14.
24. , et al. “Prevalence and Predictors of Malnutrition in Nasopharyngeal Carcinoma”. Clinical Medicine Insight: Ear, Nose and Throat 8 (2015): 19-22.
25. Silvio A., et al. “Hypoalbuminemia in Critically Ill Patients with Cancer: Incidence and Mortality”. American Journal of Hospice and Palliative Care 4 (2011): 253-257.
26. Griess B., et al. “Extracellular superoxide dismutase and its role in cancer”. Free Radical Biology and Medicine 112 (2017): 464-479.
27. Jine Li., et al. “Evaluation and Monitoring of Superoxide Dismutase (SOD) Activity and its Clinical Significance in Gastric Cancer: A Systematic Review and Meta-Analysis”. Medical Science Monitor 25 (2019): 2032-204.
28. , et al. “Human glutathione peroxidase codon 198 variant increases nasopharyngeal carcinoma risk and progression”. European Archives of Oto-Rhino-Laryngology (2021): 1-8.
29. Fetni Samira. “Le cancer du sein dans une population de femmes de l’Est algérien: facteurs de risque hormonaux, anthropométriques, du stress oxydant et des habitudes alimentaires”. Algerian Journal of Health Sciences (2020): S9-S22.

Citation

Citation: Raja Serairi Beji., et al. “Nutritional Behavior and Quantitative and Qualitative Dietary Balance in Nasopharyngeal Carcinoma Patients". Acta Scientific Gastrointestinal Disorders 5.2 (2022): 17-26.

Copyright

Copyright: © 2022 Raja Serairi Beji., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.