Ian James Martins

Department Neurosciences, Sarich Neuroscience Research Institute, Australia

*Corresponding Author: Ian James Martins, Department Neurosciences, Sarich Neuroscience Research Institute, Australia.

Received: December 29, 2021; Published: January 18, 2022

Keywords: Inflammatory Bowel Disease; Sirtuin 1; Chronic Disease; Nutrition; Therapy

The global chronic disease epidemic has become of major concern to various individuals in the developing and developed world. In the developing world the global increase in chronic diseases such as NAFLD and neurodegenerative diseases that now afflict millions of individuals in various countries is possibly associated with environmental xenobiotics [1]. The anti-aging gene sirtuin 1 (Sirt1) is involved with the regulation of various anti-aging genes that control cell survival associated with mitochondrial biogenesis and programmed cell death [2]. Interests in Sirt 1 have increased since it may repress with effects on other genes and their cellular expression with importance to the induction of obesity, diabetes, NAFLD and accelerated neurodegenerative disease [3].

References

1. Sinenchenko GI., et al. “Endolymphatic infusion of serotonin adipinate in the treatment of postoperative intestinal paresis”. Medical Bulletin of the Ministry of Internal Affairs 21.2 (2006): 21-23.
2. Arreola-Ramírez J., et al. “Modifications of plasma 5-HT concentrations during the allergic bronchoconstriction in guinea pigs”. Experimental Lung Research 7 (2013): 269-274.
3. Tamura T., et al. “Pharmacological characterization of 5-hydroxytryptamine-induced motor activity (in vitro) in the guinea pig gastric antrum and corpus”. European Journal of Pharmacology 308. 3 (1996): 315-324.
4. VI Ovsyannikov and TP Berezina. “Mechanisms of the influence of serotonin on motor activity in the duodenum, jejunum and ileum from awake rabbits”. Grown Physiology Journal M. Sechenova 8 (2002): 1017-1027.
5. Lee J., et al. “The effects of 5-HT4 receptor agonist, mosapride citrate, on visceral hypersensitivity in a rat model”. Pathology of the Digestive Diseases and Sciences 57.6 (2012): 1517-1524.
6. H Sulyman., et al. “Relation of adrenergic receptors, which have roles in gastroprotective and anti-inflammatory effect of adrenal gland hormones, with cyclooxygenase enzyme levels in rats”. Journal of Physiology and Pharmacology 4 (2009): 129-134.
7. Purohit A., et al. “Creation, expression, and characterization of a constitutively active mutant of the human serotonin 5-HT6-receptor”. Synapse3 (2003): 218-224.
8. MacLean MR and Dempsie Y. “Serotonin and pulmonary hypertension--from bench to bedside”. Current Opinion in Pharmacology 3 (2009): 281-286.
9. McKenzie C., et al. “Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5HT1B-receptor”. British Journal of Pharmacology 159.1 (2010): 188-200.
10. Kamkin AG and Kamensky AA. “Fundamental and clinical physiology, textbook”. M: "Academy" (2004).
11. Sudakov KV. “Normal physiology, textbook”. M: MIA (2006).
12. Gaiton AK and Hall DE. “Medical physiology, textbook”. M: "Logosphere" (2008).
13. Smirnov VM. “Normal physiology, textbook”. M: Academy (2012).

Citation

Citation: Ian James Martins. “Sirtuin 1 is Linked to Inflammatory Bowel Disease and Global Diseases". Acta Scientific Gastrointestinal Disorders 5.2 (2022): 12-13.

Copyright

Copyright: © 2022 Ian James Martins. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.