Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Research Article Volume 5 Issue 1

The Multidirectional Effect of Nitrite Oxide the Longitudinal and Circular Smooth Muscle Layers of the Wall of the Stomach and Duodenum

Trubitsyna IE1*, Abdulatipova ZM1, Petrakov AV1, Efremov LI1, Smirnova AV3, Tarasova TV3, Papysheva LD1, Vasilyeva IS4, Vasilyeva VV5 and Ruchkina IN1

1Moscow Clinical Scientific and Practical Center Named After A.S. Loginova, MKSC Named After A.S. Loginova, Moscow, Russia

2Mordovia State University, N.P. Ogareva, Saransk Historical and Sociological Institute, Federal State Budgetary Educational Institution of Higher Education "National Research", Russia

3Federal State Budgetary Institution “National Medical Research Oncological Center Named After N.N. Blokhin" of the Ministry of Health of Russia (FSBI National Medical Research Oncological Center Named After N.N. Blokhin of the Ministry of Health of Russia), Russia

44Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

54Candidate of Medical Sciences, Associate Professor, Associate Professor of the Department of Ambulance and Emergency Aid. Moscow Regional Research Clinical Institute. M.F. Vladimirsky, Moscow

*Corresponding Author: Trubitsyna IE, Moscow Clinical Scientific and Practical Center Named After A.S. Loginova, MKSC Named After A.S. Loginova, Moscow, Russia.

Received: November 15, 2021; Published: December 10, 2021

Abstract

In the article, conducting experimental studies on white rats of the Wistar line, we considered the effect of NO, as a mediator of inflammation in experimental colon ulcers, on smooth muscles (GM) of the stomach (G), duodenum (D) and colon (C). The experiments were carried out on white rats, of both sexes, weighing 180-220 g (average weight 200 g). The keeping of animals in the vivarium was in accordance with the sanitary rules. All experiments were carried out in accordance with the rules of humane treatment of animals. All manipulations were performed under general anesthesia in compliance with aseptic and antiseptic requirements.

To determine the level of NO in the blood serum, the nitrite/nitrate (NOx) method was used. Experimental colitis was induced by oral administration of 5% Dextran sodium sulfate (DSS) polymer solution of dactran sodium sulfate. To inhibit NO synthase, the animals were injected intraperitoneally with 1.0 ml of a 1% aqueous solution of Methylene coeruleus. a high level of NO content, due to the increased activity of the inducible form of NO-synthase, has not only a toxic effect on the mucous membrane of the colon, with a simultaneous relaxing effect on the circular and contraction of the longitudinal layer of the GM G, pyloric canal and D. The nature of the effect on all these parts of the gastroduodenal zone has a different degree of relaxation, which is the result of specific tissue homeostasis.

 

Keywords: NO; Stomach; Duodenum; Smooth Muscles

References

  1. Zverev AA., et al. “Physiology of muscles: teaching aid for students. higher. educational institutions”. Kazan, Kazan Federal University (2016): 41.
  2. KV Sudakov., et al. “Electronic edition based on: Human Physiology. Atlas of dynamic schemes: textbook”. ed. K. V. Sudakova. 2nd, Rev. and add. GEOTAR-Media (2015): 416.
  3. Lazebnik LB., et al. “The role of nitric oxide (NO) in the etiopathogenesis of some diseases of the digestive system”. Experimental and Clinical Gastroenterology 2 (2005): 4-12.
  4. Baryshnikov EN., et al. “Effect of corticosteroids on nitric oxide production in patients with inflammatory bowel diseases”. VII Congress of the Scientific Society of Gastroenterologists of Russia, dedicated to the 40th anniversary of the All-Union Scientific Research Institute of Gastroenterology - Central Research Institute gastroenterology 273-274.

Citation

Citation: Trubitsyna IE., et al. “The Multidirectional Effect of Nitrite Oxide the Longitudinal and Circular Smooth Muscle Layers of the Wall of the Stomach and Duodenum". Acta Scientific Gastrointestinal Disorders 5.1 (2022): 19-22.

Copyright

Copyright: © 2022 Trubitsyna IE., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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