Trubitsyna IE¹*, Abdulatipova ZM¹, Petrakov AV1, Efremov LI¹, Smirnova AV³, Tarasova TV³, Papysheva LD¹, Vasilyeva IS⁴, Vasilyeva VV⁵ and Ruchkina IN¹

¹Moscow Clinical Scientific and Practical Center Named After A.S. Loginova, MKSC Named After A.S. Loginova, Moscow, Russia

*Corresponding Author: Trubitsyna IE, Moscow Clinical Scientific and Practical Center Named After A.S. Loginova, MKSC Named After A.S. Loginova, Moscow, Russia.

Received: November 15, 2021; Published: December 10, 2021

Abstract

In the article, conducting experimental studies on white rats of the Wistar line, we considered the effect of NO, as a mediator of inflammation in experimental colon ulcers, on smooth muscles (GM) of the stomach (G), duodenum (D) and colon (C). The experiments were carried out on white rats, of both sexes, weighing 180-220 g (average weight 200 g). The keeping of animals in the vivarium was in accordance with the sanitary rules. All experiments were carried out in accordance with the rules of humane treatment of animals. All manipulations were performed under general anesthesia in compliance with aseptic and antiseptic requirements.

To determine the level of NO in the blood serum, the nitrite/nitrate (NOx) method was used. Experimental colitis was induced by oral administration of 5% Dextran sodium sulfate (DSS) polymer solution of dactran sodium sulfate. To inhibit NO synthase, the animals were injected intraperitoneally with 1.0 ml of a 1% aqueous solution of Methylene coeruleus. a high level of NO content, due to the increased activity of the inducible form of NO-synthase, has not only a toxic effect on the mucous membrane of the colon, with a simultaneous relaxing effect on the circular and contraction of the longitudinal layer of the GM G, pyloric canal and D. The nature of the effect on all these parts of the gastroduodenal zone has a different degree of relaxation, which is the result of specific tissue homeostasis.

Keywords: NO; Stomach; Duodenum; Smooth Muscles

References

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Citation

Citation: Trubitsyna IE., et al. “The Multidirectional Effect of Nitrite Oxide the Longitudinal and Circular Smooth Muscle Layers of the Wall of the Stomach and Duodenum". Acta Scientific Gastrointestinal Disorders 5.1 (2022): 19-22.

Copyright

Copyright: © 2022 Trubitsyna IE., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.