Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Study Volume 4 Issue 12

Chronic Pancreatitis and Malabsorption - Defects Involved and Physiological Consequences

Riddhima Banerji*

Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London

*Corresponding Author: Riddhima Banerji, Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, London.

Received: July 03, 2021; Published: November 11, 2021

Abstract

Intestinal malabsorption is a complex clinical condition with multiple adverse consequences. An understanding of the basic principles underlying the process of nutrient absorption is, therefore, essential. The normal assimilation and digestion of essential nutrients depends on the optimal motor, secretory and absorptive functions of the gastrointestinal system. The enteric nervous system plays an important role in this process. The physiology of absorption is complex. This is possibly because multiple functions of the GI system, both at the cellular and organic levels, must be carefully orchestrated together in order to bring about effective absorption and digestion. Therefore, defects in this intricate system would lead to the malabsorption of nutrients, with malnutrition as the result. The most common causes of malabsorption in the United Kingdom are coeliac disease, Crohn’s disease and chronic pancreatitis [1]. This review article will discuss the general mechanisms leading to malabsorption and then focus on chronic pancreatitis, the defects occurring in this condition, the physiological consequences of the malabsorption which occurs as a result of these defects and the clinical features arising as a consequence.

Keywords: Intestinal Malabsorption; Chronic Pancreatitis; Pancreatic Lipase; Steatorrhoea; Malnutrition

References

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  6. Ian J Martins. “Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations”. Advances in Aging Research 5 (2016): 9-26.
  7. Ian Martins. “Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome”. Journal of Clinical Epigenetics 3 (2017): 24.
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  9. Wauters E., et al. “Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer”. Cancer Research7 (2013): 2357-2367.
  10. Figure 1: Adapted from the American Journal of Managed Care, Jul (2017).

Citation

Citation: Riddhima Banerji. “Chronic Pancreatitis and Malabsorption - Defects Involved and Physiological Consequences”. Acta Scientific Gastrointestinal Disorders 4.12 (2021): 13-16.

Copyright

Copyright: © 2021 Riddhima Banerji. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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Acceptance rate35%
Acceptance to publication20-30 days

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