Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Editorial Volume 4 Issue 12

Development of Sulphasalazine a Follow through

Sajith Sebsatian*

Consultant Gastroentrologist, MGM Muthoot Hospital, Pathanamthitta, Kerala, India

*Corresponding Author: Sajith Sebsatian, Consultant Gastroentrologist, MGM Muthoot Hospital, Pathanamthitta, Kerala, India.

Received: October 11, 2021; Published: November 01, 2021

×

Abstract

It was professor Nana Svartz -1890-1986, Karolinska Institute, Stockholm, convinced that Rheumatic arthritis was caused by Streptococci. He later Hypothesised that combination with salicylic acid would deliver Sulfapyridine to affected joints. But it was only until late November 1940, when a 17yr old boy. With chronic Arthritis and colitis for 5yr was treated with Sulfapyridine in hospital for 9 months and later followed by sulphasalazine. His Colitis responded rapidly and he improved within a few months and later discharged. It was the then realised that colitis patients responded better than Rheumatic arthritis. This lead to the usage of sulfa drugs in patients with colitis and arthritis during that time. Mesalamine, it was discovered as the active anti-inflammatory moiety of sulfasalazine, which has been used to treat ulcerative colitis since the late 1940s. Sulfasalazine contains mesalamine or 5 ASA bound to sulfapyridine via an azo bond. It is released by bacterial enzyme azo reductase present in the small bowel and colon. Sulfapyridine is inactive, but is absorbed in the colon and is mostly responsible for hypersensitivity reactions and adverse effects associated with sulfasalazine. It is then excreted in the urine as free 5-ASA and N-Ac-5-ASA. Most of the side effects of salazopyrine drugs were attributed due to Sulfapyridine. Mesalamine compared were absorbed rapidly from gut and pre-systemically acetylated.

×

References

×

Citation

Citation: Sajith Sebsatian. “Development of Sulphasalazine a Follow through". Acta Scientific Gastrointestinal Disorders 4.11 (2021): 72-83.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 15, 2022.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US