Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 4 Issue 11

Сlinical Case and Management of a Patient with Gastroenterological Disorders in Type 2 Diabetes Mellitus

Yu V Chychula*

Bogomolets National Medical University, Kyiv, Ukraine

*Corresponding Author: Yu V Chychula, Bogomolets National Medical University, Kyiv, Ukraine.

Received: September 06, 2021; Published: October 25, 2021

×

Abstract

Both Diabetes mellitus (DM) and viral hepatitis are relevant when it comes to the discussion of medical and social health problems. Annually worldwide, the number of patients with type 2 diabetes mellitus (T2DM) increases by 7 million people. Hypoacid conditions and achlorhydria are noted in 60% of patients with chronic atrophic gastritis. Therefore, in addition to disorders of motor function of the stomach, patients with T2DM develop significant metabolic changes in the mucous membrane of the gastroduodenal zone. Some antioxidants are synthesized and activated by the liver, in particular transferrin, ceruloplasmin. T2DM is a manifestation of the metabolic syndrome associated with insulin resistance and is a generally accepted risk factor for non-alcoholic fatty liver disease. Increased activity of liver enzymes in the blood serum may indicate T2DM acts as extrahepatic manifestations of chronic viral hepatitis C.

Hepatitis C is one of the most dangerous liver diseases of viral etiology, the prevalence of which is growing every year. The peculiarity of chronic viral hepatitis C the presence extrahepatic manifestations. The frequency of extrahepatic manifestations in chronic hepatitis C varies from 38% to 74%.

According to modern ideas of pathogenesis, type 2 diabetes mellitus (T2DM) is considered as an extrahepatic manifestation of chronic viral hepatitis C, and chronic viral hepatitis C is considered as an etiological factor in the development of T2DM.

The prevalence of T2DM in patients with viral liver disease is 6-10 times higher than in the general population.

Many patients with extrahepatic manifestations, which are predominant in the clinical picture, may not suspect that they are carriers of viral infection HCV.

The prevalence of Iron deficiency anemia among the adult population is 2% - 6%. Recently, the relationship between iron deficiency and metabolic syndrome, prediabetes, and T2DM has been studied. Iron deficiency anemia is much more common in patients with type 2 diabetes mellitus. Iron deficiency can disrupt glucose homeostasis and therefore have a negative effect on glycemic control.

The clinical case presented in the article demonstrates the comorbidity of the lesion of the gastrointestinal tract in a patient with T2DM and is of interest to medical doctors.

Keywords: Type 2 Diabetes; Chronic Atrophic Gastritis; H. pylori; Chronic Viral Hepatitis C; Fecal Calprotectin, Fecal Elastase 1; Iron Deficiency Anemia; Sideropenic Syndrome

×

References

  1. Hepatitis C. Key facts.
  2. GLOBAL HEALTH SECTOR STRATEGY ON VIRAL HEPATITIS 2016–2021, Geneva.
  3. Golubovskaya OA., et al. “Correction of polyneuropathy in type II diabetes mellitus in patients with chronic hepatitis C”. Clinical Infectiology and Parasitology04 (2013): 141-150.
  4. Golubovska O. “Epidemiology and a natural curse of a virus C hepatitis”. Clinical Endocrinology and Endocrine Surgery 25 (2008): 48-51.
  5. Broide E., et al. “Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia”. Journal of Diabetes Research 6 (2018): 7494821.
  6. Younossi Z., et al. “Extrahepatic Manifestations of Hepatitis C: A Meta-analysis of Prevalence, Quality of Life, and Economic Burden”. Gastroenterology7 (2016): 1599-1608.
  7. Cacoub P., et al. “Extrahepatic manifestations of chronic hepatitis C virus infection”. Therapeutic Advances in Infectious Disease 1 (2016): 3-14.
  8. Durand F and Valla D. “Assessment of prognosis of cirrhosis”. Seminars in Liver Disease 1 (2008): 110-122.
  9. El-Serag HB. “Epidemiology of viral hepatitis and hepatocellular carcinoma”. Gastroenterology6 (2012): 1264-1273.e1.
  10. Global hepatitis report. Geneva: World Health Organization (2017).
  11. Hui JM., et al. “Insulin resistance is associated with chronic hepatitis C and fibrosis progression”. Gastroenterology 125 (2003): 1695-1704.
  12. Mason AL., et al. “Association of diabetes mellitus and chronic hepatitis C virus infection”. Hepatology 29 (1999): 328-333.
  13. Merlo ChM and Wuillemin WA. “Prevalence and causes of anemia in a city general practice”. Praxi13 (2008): 713-718.
  14. Younossi ZM., et al. “Hepatitis C infection: a multifaceted systemic disease with clinical, patient reported and economic consequences”. The Journal of Hepatology1 (2016): S109-S19.
×

Citation

Citation: Yu V Chychula. “Сlinical Case and Management of a Patient with Gastroenterological Disorders in Type 2 Diabetes Mellitus”. Acta Scientific Gastrointestinal Disorders 4.11 (2021): 43-47.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is November 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US