Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 4 Issue 10

Use of Plasmapheresis: Acute Pancreatitis Due to Hypertriglyceridemia: Case Report

Danny Fernado Silva Cevallos*, Diana Evangelista Barragan, Mirella Barrera Rivera, Casar Arreaga Perez, Angelica Zarate Zapata and Fernando Silva Michalon

Department of Emergency/Internal Medicine, Guayaquil Clinical Hospital, Ecuador

*Corresponding Author: Danny Fernado Silva Cevallos, Department of Emergency/Internal Medicine, Guayaquil Clinical Hospital, Ecuador.

Received: August 31, 2021; Published: September 20, 2021


  Hypertriglyceridemic pancreatitis (PATG) is described as an uncommon cause with an incidence that ranges from 2 to 4% of cases, generates significant morbidity and mortality between 40 per 100,000 inhabitants in a western population [1,2]. There are several pathophysiological mechanisms that explain the appearance of pancreatitis caused by hypertriglyceridemia, one of them is the direct toxic role of free fatty acids on pancreatic tissue and another widely accepted mechanism is chylomicron-mediated vascular obstruction, given the decrease in the gene expression of lipoprotein lipase (LPL) [3]. The American Society for Apheresis (ASFA) indicates the use of plamapheresis when there is severe pancreatitis, when triglyceride levels exceed more than 2000 mg/dl and when there is no satisfactory response to first-line treatment; the success of the treatment is based on a decrease in triglycerides below 500 mg/dl to achieve the goal of using plasmapheresis [4]. In this case, it was demonstrated that the timely assessment of the patient was essential to make treatment decisions in the appropriate time with a favorable response to it.

Keywords: Acute Pancreatitis, Hypertriglyceridemia, Plasmapheresis, Triglycerides


  1. Joglekar K., et al. “Therapeutic plasmapheresis for hypertriglyceridemia-associated acute pancreatitis: case series and review of the literature”. Therapeutic Advances in Endocrinology and Metabolism 4 (2017): 59-65.
  2. Sánchez RAMR., et al. “Utilidad de la plasmaféresis en la pancreatitis aguda por hipertrigliceridemia”. Revista colombiana de Gastroenterología2 (2020): 226-231.
  3. Garg R and Rustagi T. “Management of Hypertriglyceridemia Induced Acute Pancreatitis”. BioMed Research International Hindawi (2018).
  4. Marín-Sánchez JA., et al. “Pancreatitis aguda severa por hipertrigliceridemia en el adulto: Presentación de caso clínico, diagnóstico y tratamiento”. Revista colombiana de Gastroenterología 4 (2018): 459-463.
  5. Severe Hypertriglyceridemia‐Related Acute Pancreatitis - Stefanutti - 2013 - Therapeutic Apheresis and Dialysis - Wiley Online Library (2013).
  6. Herrera Del Águila DD., et al. “Pancreatitis aguda por hipertrigliceridemia severa: reporte de caso y revisión de la literature”. Revista de Gastroenterología del Perú 2 (2015): 159-164.
  7. Rawla P., et al. “Hypertriglyceridemia-induced pancreatitis: updated review of current treatment and preventive strategies”. Clinical Journal of Gastroenterology 6 (2018): 441-448.
  8. Senosiain Lalastra C., et al. “Pancreatitis aguda por hipertrigliceridemia”. Clinical Gastroenterology and Hepatology 4 (2013): 274-279.
  9. Izquierdo-Ortiz MJ and Abaigar-Luquin P. “Hipertrigliceridemia severa: Tratamiento con plasmaféresis”. Nefrol Madr.3 (2012): 417-418.
  10. Song X., et al. “Intensive insulin therapy versus plasmapheresis in the management of hypertriglyceridemia-induced acute pancreatitis (Bi-TPAI trial): study protocol for a randomized controlled trial”. Trials1 (2019): 365.
  11. Montaño-Padilla GS., et al. “The usefulness of plamapheresis in acute pancreatitis due to hypertriglyceridemia: A case report”. Revista colombiana de Gastroenterología 2 (2020): 226-231.


Citation: Danny Fernado Silva Cevallos., et al. “Use of Plasmapheresis: Acute Pancreatitis Due to Hypertriglyceridemia: Case Report”. Acta Scientific Gastrointestinal Disorders 4.10 (2021): 39-42.


Copyright: © 2021 Danny Fernado Silva Cevallos., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US