Aimun Raees and Wasim Jafri*
Department of Medicine Gastroenterology, Aga Khan University, Karachi, Pakistan
*Corresponding Author: Wasim Jafri, Department of Medicine Gastroenterology, Aga Khan University, Karachi, Pakistan.
July 13, 2021; Published: August 16, 2021
Eosinophilic Esophagitis (EoE) is a long-standing, relapsing immune-mediated esophageal disorder, facilitated by atopy, resulting in dysphagia and esophageal strictures. The prevalence has been leaping in the last few decades consistent with the enhanced understanding of the disease. It occurs in people from all ages but children and young males are especially affected. A wide spectrum of factors has been associated with it, including genetic and environmental risk factors. In atopic individuals, interaction of allergens with the esophageal epithelium generates a T-helper cells type2 driven immune response, which leads to the activation of inflammatory cytokines which in turn induce various genes causing formation and recruitment of eosinophils as well as mast cells setting in a chronic inflammatory process. Diagnosis is made on typical clinical, endoscopic and histological factors. Therapeutic modalities range from dietary restriction to corticosteroid therapy. Endoscopic intervention may be needed for patients presenting with esophageal strictures. Recently, biological agents have also been under trials for its treatment but there is no FDA approved drug therapy available as yet. It is a relatively new disorder that is constantly under evolution in terms of diagnostic and therapeutic fields.
Keywords: Eosinophilic Esophagitis; Dysphagia; Food Impaction; Esophageal Stricture; Atopic Disorder
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