Lebedeva VD*, Pastukhova OA and Sokolov DE

First St. Petersburg State medical University Named After Academician I.P. Pavlova, Institute of Evolutionary Physiology and Biochemistry Named After I.M. Sechenov Russian Academy of Sciences, Russia

*Corresponding Author: Lebedeva VD, First St. Petersburg State medical University Named After Academician I.P. Pavlova, Institute of Evolutionary Physiology and Biochemistry Named After I.M. Sechenov Russian Academy of Sciences, Russia.

Received: July 29, 2021; Published: August 10, 2021

  Many different theories of the pathogenesis of hypertension have been created, but the true mechanism of its course remains unclear to this day. The article discusses the concept of hypertension as a neurosis of the higher autonomic centers, which is transformed into a metabolic syndrome.

  The processes occurring during hypertension in the body are regulated by the autonomic nervous system. Inhibition of the noradrenergic system and a decreased level of noradrenaline in the blood are associated with an increase in blood pressure and lead to the activation of the cholinergic system. This activation causes impaired blood flow and damage to the vascular endothelium, which contributes to arterial hypertension.

References

1. Shlyakhto EV and Konradi AO. “Classification of arterial hypertension: from Bright's disease to the cardiovascular continuum”. Arterial Hypertension2 (2004): 98-103. [Shlyakhto E. V., Konradi A. O. Classification of Arterial Hypertension: from Bright Disease to Cardiovascular Continuum. Arterial'naya Gipertenziya. 2004; Vol. 10 (2): 98-103. (In Russian)].
2. Lang GF. “Hypertonic disease. L.: Medgiz, Leningrad. Separation (1950). [Lang GF. “Hypertonic Disease”. Leningrad: Medgiz (1950). (In Russian)].
3. Postnov YuV and Orlov SN. “Primary hypertension as a pathology of cell membranes”. M.: Medicine (1987). [Postnov YuV and Orlov SN. “Primary hypertension as a pathology of cell membranes”. Moscow: Meditsina (1950). (In Russian)].
4. Postnov YuV., et al. “Disruption of energy conversion in cell mitochondria with a decrease in ATP synthesis as a cause of a stationary increase in the level of systemic arterial pressure”. Cardiology8 (2008): 49-59. [Postnov YuV., et al. “Violation of energy conversion in mitochondria of cells with a decrease in ATP synthesis as a cause of a stationary increase in systemic blood pressure”. Kardiologiya 48.8 (2008): 49-59. (In Russian)].
5. Leshchenko VG and Ilyich GK. “Medical and biological physics: textbook”. M.: INFRA-M; Minsk: New knowledge (2017). [Leshchenko VG and Il'ich GK. “Medical and Biological Physics: Textbook”. Moscow: INFRA-M; Minsk: Novoe Znanie (2017). (In Russian)].
6. Halperin SI. “Human anatomy and physiology (age characteristics with the basics of school hygiene): textbook”. 2^nd M.: Higher school (1974). [Gal'perin SI. “Human anatomy and physiology (age-related features with the basics of school hygiene): Textbook”. 2^nd edition. Moscow: Vysshaya Shkola (1974). (In Russian)].
7. Leshchenko VG and Ilyich GK. “Medical and biological physics: textbook”. Minsk: New knowledge: INFRA-M (2012). [Leshchenko VG and Il'ich GK. “Medical and Biological Physics: Textbook”. Minsk: Novoe Znanie: INFRA-M (2012). (In Russian)].
8. Adrian ED and Yamagiwa K. “The origin of the Berger Rhythm”. Brain 3 (1935): 323-351.
9. Adrian ED. “Basics of sensations”. M.: State. honey. publishing house (1931). [Adrian ED. “The basis of sensation”. Moscow: Gosudarstvennoe meditsinskoe izdatel'stvo (1931). (In Russian)].
10. Medvedev BA. “Pharmacological study of clonidine”. Pharmacology and Toxicology 3 (1977): 288-296. [Medvedev BA. “Pharmacological study of clonidine”. Farmakologiya I Toksikolkgiya 3 (1977): 288-296. (In Russian)].
11. Gogin EE., et al. “Arterial hypertension”. L.: Medicine, Leningrad. Department (1978). [Gogin EE., et al. “Arterial hypertension”. Leningrad: Meditsna (1950). (In Russian)].
12. Kushakovsky MS. “Hypertension and secondary arterial hypertension”. Edition. 3, erased. L.: Medicine; (1983). [Kushakovskiy MS. “Hypertension and secondary arterial hypertension”. Edition. 3, erased. Leningrad: Meditsna (1983). (In Russian)].
13. Lebedeva VD. “Pathogenetic method of treatment of patients with essential hypertension, taking into account its metabolic mechanisms”. Clinical Pathophysiology3 (2017): 23-28. [Lebedeva VD. “Pathogenetic method of treating patients with hypertension taking into account its metabolic mechanisms”. Klinicheskaya Patofiziologiya 23.3 (2017): 23-28. (In Russian)].
14. Golikov SN., et al. “Cholinergic regulation of biological systems of the cell”. M.: Medicine (1985). [Golikov SN., et al. “Cholinergic regulation of cell biological systems”. Moscow: Meditsna (1985). (In Russian)].
15. Guyton AK and Hall JE. “Medical Physiology: Textbook”. M.: Logosphere (2008). [Guyton Arthur C and Hall John E. “Medical Physiology: Textbook”. Moscow: Logosfera (2008). (In Russian)].
16. Kanungo MS. “Biochemistry of aging”. M.: Mir (1982). [Kanungo MS. “Biochemistry of Aging”. Moscow: Mir (1982). (In Russian)].
17. Ivanova NV. “Effect of propranolol on the volume of extracellular fluid, renin activity, plasma aldosterone concentration and central hemodynamics in patients with stage II hypertension”. Dissertation. L (1983). [Ivanova NV. “The effect of propranolol on extracellular fluid volume, renin activity, plasma aldosterone concentration and central hemodynamics in patients with stage II hypertension”. The dissertation. Leningrad (1983). (In Russian)].
18. Skulachev VP., et al. “Membrane bioenergy: textbook”. Moscow: Moscow University Publishing House; (2010). [Skulachyov VP., et al. “Membrane Bioenergy: A Training Manual”. Moscow: Moscow University Press (2010). (In Russian)].
19. Костенко ВГ. “Живая клетка глазами химика-органика. СПб.: ВВМ (2009). [Kostenko VG. “Living cell through the eyes of an organic chemist”. Saint Petersburg: BBM (2009). (In Russian)].
20. Selye HA. “Syndrome produced by Diverse Nocuous Agents”. Nature 3479 (1936): 32.
21. Rob AI. “The relationship of endocrine complexes under stress”. Chisinau: Shtiintsa (1982). [Robu AI. “The relationship of endocrine complexes under stress”. Chisinau: Stiincea (1982). (In Russian)].
22. Raitsek DE., et al. “Secrets of arterial hypertension”. M.: BINOM (2005). [Hricik Donald E., et al. “Hypertension secrets”. Moscow: BINOM (2005). (In Russian)].
23. Meerson FZ. “Pathogenesis and prevention of stress and ischemic heart damage”. M.: Medicine (1984). [Meerson FZ. “Pathogenesis and prevention of stress and ischemic heart damage”. Moscow: Meditsna (1984). (In Russian)].
24. Zaichik ASh and Churilov LP. “General pathophysiology (with the basics of immunopathology): A textbook for students of medical universities. 4^th SPb: ELBI 1 (2008). [Zaychik A and Sh Churilov LP. “General pathophysiology (with the basics of immunopathology): A textbook for students of medical universities”. 4^th edition. T.1. Saint Petersburg: ELBI (2008). (In Russian)].

Citation

Citation: Lebedeva VD., et al. “Physiological Bases of Hypertension”. Acta Scientific Gastrointestinal Disorders 4.9 (2021): 12-15.

Copyright

Copyright: © 2021 Lebedeva VD., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.