Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India
*Corresponding Author: Akanksha Singh, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India.
Received: July 12, 2021; Published: July 26, 2021
Citation: Akanksha Singh. “Molecular Crosstalk amongst Anti-Orexigenic Ghrelin and Adenosine Monophosphate-Activated Protein Kinase (AMPK)". Acta Scientific Gastrointestinal Disorders 4.8 (2021): 66-67.
Ghrelin has proved to be a crucial mediator in stimulation of obesity. It elevates appetite by eliminating the action of GHS-R1a of neurological NPY/AgRP thus enhancing orexigenic activity. Such negative effects had been neutralized by the production of auto-ghrelin antibodies which are self-catalytic neutralizing the obese conditions by directly targeting AMPK active site which is known to stimulate appetite. Suppression of AMPK thus playing a central role might stimulate the activation of GHS-R1a thus leading to controlled release of ghrelin hormone. In this study, when mice were fed with high calorie diet exposed to the anti- ghrelin antibodies prepared by ELISA technique, after few hours, anti- ghrelin showed maximum activity thus decreasing ghrelin levels originally present. The study mainly focusses on the determining the interaction occurring between obese mediated ghrelin molecule and AMPK.
Keywords: Ghrelin; GHS-R1a; NPY/AgRP; Orexigenic; AMPK; ELISA; Obesity
Copyright: © Akanksha Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.