Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091)

Short CommunicationVolume 4 Issue 8

CRISPR Genome Editing: A Boon to Medical Science

Hemshankar Laugi*

Department of Biology, Bal Kalyan Vidhya Mandir Ma. Vi., Nepal

*Corresponding Author: Hemshankar Laugi, Department of Biology, Bal Kalyan Vidhya Mandir Ma. Vi., Nepal.

Received: July 07, 2021; Published: July 20, 2021

Citation: Hemshankar Laugi. “CRISPR Genome Editing: A Boon to Medical Science”. Acta Scientific Gastrointestinal Disorders 4.8 (2021): 38-39.

  CRISPR, an acronym for Clustered Regularly Interspaced Short Palindromic Repeats, is one of the major discoveries in the field of medical science. It is a type of bacterial adaptive immunity used to fight against bacteriophages. It is a type of memory. Whenever a virus attacks a bacterium for the first time, it creates a memory which is used to fight with that virus if it attacks the second time. In this system, small guide RNAs (crRNAs) are employed for sequence-specific interference with invading nucleic acids. CRISPR-Cas comprises a genomic locus called CRISPR that has short repetitive elements (repeats) separated by unique sequences (spacers), which can originate from mobile genetic elements (MGEs) such as bacteriophages, transposons, or plasmids [1].

Bibliography

  1. Hille F and Charpentier E. “CRISPR-Cas: biology, mechanisms and relevance. Philosophical transactions of the Royal Society of London”. Series B, Biological Sciences1707 (2016): 20150496.
  2. Fineran PC and Charpentier E. “Memory of viral infections by CRISPR-Cas adaptive immune systems:acquisition of new information”. Virology 434 (2012): 202-209.
  3. Gholizadeh P., et al. “How CRISPR-Cas System Could Be Used to Combat Antimicrobial Resistance”. Infect Drug Resist 13 (2020): 1111-1121.
  4. Xu CL., et al. “Viral Delivery Systems for CRISPR”. Viruses1 (2019): 28.
  5. Montaño A., et al. “Targeted genome editing in acute lymphoblastic leukemia: a review”. BMC Biotechnology1 (2018): 45.
  6. Ayanoğlu FB., et al. “Bioethical issues in genome editing by CRISPR-Cas9 technology”. Turkish Journal of Biology = Turk Biyoloji Dergisi 2 (2020): 110-120.
  7. Maryam Mehravar., et al. “Mosaicism in CRISPR/Cas9-mediated genome editing”. Developmental Biology 2 (2019): 156-162.

Copyright: © 2021 Hemshankar Laugi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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