Alimohammad Bananzadeh, Ali Daneshvar Jahromi, Amirhossein Emami Meybodi, Seyed Mohammad Kazem Tadayon* and Mohammad Rezazadehkermani
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
*Corresponding Author: Seyed Mohammad Kazem Tadayon, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Received: October 05, 2020; Published: October 22, 2020
Purpose: Recurrence of colorectal cancers is considered to be one of the greatest post-surgical complications that is affected by various factors. This study design to investigate the prognostic factors that affect the recurrence and survival of patients with colon and rectal cancer.
Methods: A retrospective study was performed in 380 patients with colon and rectal cancer who underwent surgery; type of surgery, tumor size, differentiation grade, proximal, distal and radial, marginal involvement, total number of excision lymph nodes, number of involved lymph nodes and tumor stage was recorded. Also, the incidence of recurrence and metastasis was recorded during the study.
Results: 380 patients with mean age of 57.11 were enrolled to the study. 152 patients with an average age of 57.57 were diagnosed with colon cancer. Recurrence and metastasis occurred in 2 patients (1.3%) and 5 patients (3.3%), respectively. 18 patients (11.8%) died due to colon cancer. 228 patients with a mean age of 56.81 had rectal cancer. Recurrence was seen in 19 patients (8.3%) and metastasis in 33 patients (14.5%). 38 patients (16.7%) died due to rectal cancer. Tumor size and involved lymph nodes were independent prognosis factors of recurrence and metastases of colon cancer. Only involved lymph nodes were associated with death due to colon cancer. Independent prognostic factors of rectal cancer metastasis included albumin and age. The total number of excision lymph nodes was the only predictor factor of tumor recurrence and death in rectal cancer. The median survival time of colon and rectal cancers were 90 and 110 months, respectively.
Conclusion: The size of the tumor and the number of involved lymph nodes were independent prognostic factors for recurrence and metastasis of colon cancer. Also, the number of involved lymph nodes was associated with colon cancer related death. In the case of rectal cancer, albumin levels and age predicted metastases. Only total number of excision lymph nodes had reverse relationship with recurrence and rectal cancer related death.
Keywords: Colorectal Neoplasms; Neoplasm Recurrence; Neoplasm Metastasis; Lymphatic Metastasis; Survival
Citation: Seyed Mohammad Kazem Tadayon., et al. “Survey the Prognostic Factors of Recurrence and Survival in Patients with Colorectal Cancer". Acta Scientific Gastrointestinal Disorders 3.11 (2020): 28-34.
Copyright: © 2020 Seyed Mohammad Kazem Tadayon., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.