Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 3 Issue 11

Spontaneous Bacterial Peritonitis in Cirrhotic Patients: Triggering Receptor Expressed on Myeloid Cells (TREM-1) as a Valid Marker

Nadia A Abdelkader1, Waheed Abd El Monsef1, Ahmed F Helal1, Ghada A Ismail2, Dalia H Abdelhamid2, Maha M El Gaafary3, Khaled Raafat4, Yasser A Abd El Razek1 and Ahmed Fouad Sherief1*

1Tropical Medicine Department, Ain Shams University, Cairo, Egypt
2Clinical Pathology Department, Ain Shams University, Cairo, Egypt
3Public Health and Community Medicine, Ain Shams University, Cairo, Egypt
4Internal Medicine, Gastroenterology and Hepatology, Ain Shams University, Cairo, Egypt

*Corresponding Author: Ahmed Fouad Sherief, Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Abbasia, Cairo, Egypt.

Received: September 24, 2020; Published: October 22, 2020

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Abstract

Purpose: Assessment of Triggering Receptor Expressed on Myeloid Cells (TREM-1) levels in the diagnosis of SBP and effectiveness of treatment among Egyptian cirrhotic ascitic patients.

Methods: This was a Prospective case-control study, which was conducted on 60 cirrhotic ascitic patients, and divided into two groups:

  • Group 1: (Control) 30 cirrhotic ascitic patients without SBP
  • Group 2: (SBP) 30 cirrhotic ascitic patients with SBP were admitted to the Tropical Medicine Department at Ain Shams University Hospitals with ascites due to chronic liver disease. All patients were subjected to a history of taking the clinical examination and laboratory investigations including ascitic fluid sampling for biochemical testing, total and predominant cell type, count of bacterial culture, and TREM-1 level.

Results: There was a high statistically significant difference between the two groups in the baseline level of TREM-1 while the mean was higher 1280 pg/ml (± 1136.9) with a level range between (580 - 4500 pg/ml) among patients with SBP Than the control group mean 129.9 pg/ml (± 51.9) with a level range between (60 - 250 pg/ml) among. Besides, it was found a statistically significant difference in the level of TREM-1 before and after treatment among patients with SBP. The mean of TREM-1 before treatment was higher 1280.6 pg/ml (± 1136.9) than a mean 376.2 pg/ml (± 78.4) and level range between (260 - 560 pg/ml) after the treatment.

Conclusion: TREM-1 is an easy, rapid, and reliable diagnostic tool for SPB which also harbors great value in following up patients with SBP.

Keywords: CLD; Ascites; Spontaneous Bacterial Peritonitis; Ascitic TREM-1 Level; Ascitic Culture

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References

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Citation

Citation: Ahmed Fouad Sherief., et al. "Spontaneous Bacterial Peritonitis in Cirrhotic Patients: Triggering Receptor Expressed on Myeloid Cells (TREM-1) as a Valid Marker". Acta Scientific Gastrointestinal Disorders 3.11 (2020): 23-27.




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