Abstract

Purpose: Assessment of Triggering Receptor Expressed on Myeloid Cells (TREM-1) levels in the diagnosis of SBP and effectiveness of treatment among Egyptian cirrhotic ascitic patients.

Methods: This was a Prospective case-control study, which was conducted on 60 cirrhotic ascitic patients, and divided into two groups:

• Group 1: (Control) 30 cirrhotic ascitic patients without SBP
• Group 2: (SBP) 30 cirrhotic ascitic patients with SBP were admitted to the Tropical Medicine Department at Ain Shams University Hospitals with ascites due to chronic liver disease. All patients were subjected to a history of taking the clinical examination and laboratory investigations including ascitic fluid sampling for biochemical testing, total and predominant cell type, count of bacterial culture, and TREM-1 level.

Results: There was a high statistically significant difference between the two groups in the baseline level of TREM-1 while the mean was higher 1280 pg/ml (± 1136.9) with a level range between (580 - 4500 pg/ml) among patients with SBP Than the control group mean 129.9 pg/ml (± 51.9) with a level range between (60 - 250 pg/ml) among. Besides, it was found a statistically significant difference in the level of TREM-1 before and after treatment among patients with SBP. The mean of TREM-1 before treatment was higher 1280.6 pg/ml (± 1136.9) than a mean 376.2 pg/ml (± 78.4) and level range between (260 - 560 pg/ml) after the treatment.

Conclusion: TREM-1 is an easy, rapid, and reliable diagnostic tool for SPB which also harbors great value in following up patients with SBP.

Keywords: CLD; Ascites; Spontaneous Bacterial Peritonitis; Ascitic TREM-1 Level; Ascitic Culture

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Citation

Citation: Ahmed Fouad Sherief., et al. "Spontaneous Bacterial Peritonitis in Cirrhotic Patients: Triggering Receptor Expressed on Myeloid Cells (TREM-1) as a Valid Marker". Acta Scientific Gastrointestinal Disorders 3.11 (2020): 23-27.

Copyright

Copyright: © 2020 Ahmed Fouad Sherief., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.