Acta Scientific Gastrointestinal Disorders (ASGIS)(ISSN: 2582-1091)

Case Report Volume 3 Issue 10

A Study on the Challenges of Diagnosis and Interpretation in the Subject with Intestinal Ganglioneuromatosis

Kadir Bal1, Sibel Erdamar2, Bilgi Baca3, Uğur Korman4 and Erkan Çağlar1*

1Gastroenterology Division, Cerrahpasa Medical Faculty, Istanbul University, Istanbul
2Pathology Department, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul
3General Surgery Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul
4Radiology Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul

*Corresponding Author: Erkan Çaglar, Gastroenterology Department, Cerrahpasa Medical Faculty, Istanbul University, Istanbul.

Received: July 29, 2020; Published: September 24, 2020

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Abstract

 Diffuse intestinal ganglioneuromatosis is hamartomatous polyposis distinguished by a scattered, intramural or transmural proliferation of neural elements involving the enteric plexuses. This condition may involve any segment of the gastrointestinal tract, but the ileum, colon, and appendix are most frequently affected. It is a rare, benign neoplastic condition that has a well known association with multiple endocrine neoplasia type 2b, Cowden syndrome and a rare but documented association with neurofibromatosis type 1. We reported the case of a female patient's history of a neurofibromatosis who presented with chronic diarrhea. On the CT scan of the abdomen, thickening of the wall up to 2 cm, air-fluid leveling and dilatation reaching up to 6 cm at its maximum in the ileal segments and mesentery lymphadenopathies and intraperitoneal effusion were reported. There was not any peculiarity except ileal oedema and erythema on the colonoscopic examination. Endoscopic biopsy specimens obtained from the terminal ileum showed acute inflammation without any definitive findings of Crohn’s disease. Due to intestinal obstruction, the patient underwent surgical resection. Diffuse ganglioneuromatosis was observed in the resected specimen.

Keywords: Intestinal Ganglioneuromatosis; Neurofibromatosis; Diarrhea; Crohn's Disease

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Citation

Citation: Erkan Çağlar., et al. “A Study on the Challenges of Diagnosis and Interpretation in the Subject with Intestinal Ganglioneuromatosis". Acta Scientific Gastrointestinal Disorders 3.10 (2020): 14-16.




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