Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091)

Editorial Volume 3 Issue 10

Back to the Future: HLA in Gastroenterology

Hakim Rahmoune1,2*, Mounira Amrane1, Hadia Ziada-Bouchaar3,4, Dalila Satta3 and Nada Boutrid1,2

1LMCVGN Research Laboratory, Faculty of Medicine, Setif-1 University, Algeria
2Department of Pediatrics, University Hospital of Setif, Algeria
3Faculty of Natural and Life Sciences, Molecular and Cellular Biology Laboratory, University of Constantine 1 Mentouri Brothers, Constantine, Algeria
4Department of Animal Biology, Faculty of Natural and Life Science, University 1, Mentouri Brothers, Constantine, Algeria

*Corresponding Author: Hakim Rahmoune, LMCVGN Research Laboratory, Faculty of Medicine, Setif-1 University, Algeria.

Received: August 10, 2020; Published: August 24, 2020


Celiac disease (CD) and inflammatory bowel diseases (IBD) are among the most common gastrointestinal disorders and share strong genetic risks that may predict their diagnosis or even guide their management, particularly the Human Leukocyte Antigen (HLA) system.

Historically, various associations between the HLA and autoimmune diseases were reported since the 1970s, and the HLA is now incriminated in a myriad of diseases including CD and IBD [1,2].



  1. Rahmoune H., et al. “HLA and Celiac Disease”. Moroccan Health Journal 18 (2017): 14-15.
  2. Pallav K., et al. “Clinical utility of celiac disease-associated HLA testing”. Digestive Diseases and Sciences 59 (2014): 2199-206.
  3. Cruz-Tapias P., et al. “Major histocompatibility complex: Antigen processing and presentation”. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press (2013).
  4. Martina S., et al. “Genetic susceptibilty and celiac disease: what role do HLA haplotypes play?”. Acta Bio Medica: Atenei Parmensis 89 (2018): 17.
  5. Rahmoune H., et al. “Celiac Disease, Diabetes and Crohn Disease: An Autoimmune Implosion?”. International Journal of Celiac Disease 6.2 (2018): 62-63.
  6. Rahmoune H., et al. “HLA genes as a predictive screening tool for celiac disease”. Turkish Archives of Pediatrics 52 (2017): 182-184.
  7. G Husby S., et al. “European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease”. Journal of Pediatric Gastroenterology and Nutrition 54 (2012): 136-160. 
  8. Ashton JJ., et al. “Review article: the genetics of the human leucocyte antigen region in inflammatory bowel disease”. Alimentary Pharmacology and Therapeutics 50.8 (2019): 885-900.
  9. Sazonovs A., et al. “HLA-DQA1* 05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn’s disease”. Gastroenterology 158.1 (2020): 189-199.
  10. Charron D. “HLA, immunogenetics, pharmacogenetics and personalized medicine”. Vox Sang 100.1 (2011): 163-166.


Citation: Hakim Rahmoune., et al. “Back to the Future: HLA in Gastroenterology”. Acta Scientific Gastrointestinal Disorders 3.10 (2020): 01-02.


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Acceptance to publication20-30 days

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