Abstract

Background: Splanchnic vein thrombosis (SVT) is an uncommon, but potentially life-threatening disease. An etiologic factor can be identified in about 25 - 75% of patients as reported in western literature. This study was done to evaluate thrombotic factors including JAK2V617F mutation in patients with SVT.

Aim: To evaluate clinical and etiological profile of patients with splanchnic venous thrombosis.

Methods: All patients with SVT diagnosed with CECT abdomen attending our institute from April 2011 to May 2013 were screened. Patients with malignancy, intra-abdominal inflammatory conditions or surgery in the preceding three months were excluded. A thrombophilia work-up (protein C, S and AT-III deficiency, APCR, ACLA and LA, homocysteine level and JAK2V617F mutation) was done.

Results: Total 39 patients were included (mean age: 45.9 ± 15.2 years; M:F  1.6:1). 29 patients (74.3%) had portal vein thrombosis (PVT), 6 (15.4%) had BCS and 4 (7.6%) had isolated mesenteric vein thrombosis. Isolated PVT was found in 8/29 (27.5%). 21/29 (72.5%) had additional one or more accessory vein involved. Site of thrombosis in BCS patients was in HV (50%), HV and IVC (33.3%) and HV and PV (16.7%). The common symptoms were abdominal pain (48%), ascites (38.5%), pedal edema (30%), splenomegaly (25.6%) and gastrointestinal bleeding (15%). 23% (9/39) patients were asymptomatic. Cirrhosis was found in 10/29 (34.4%) patients in PVT group. 50% patients had one thrombotic factor, 30% had two or more factors and 20% had none. JAK2V617F mutation was found in 5/39 (12.8%) patients. None of the cirrhotic patients had JAK2V617F mutation.

Conclusion: Splanchnic vein thrombosis usually presents as a chronic disease. A prothrombotic state was detected in 80% of patients. JAK2V617F mutation was detected in 12.8% patients.

Keywords: Splanchnic Venous Thrombosis (SVT); Tertiary Care Centre; Thrombophilia

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Citation

Citation: Pawar Abhimanrao Manikrao., et al. “Clinical and Etiological Profile of Patients with Splanchnic Venous Thrombosis in a Tertiary Care Centre from Southern India”. Acta Scientific Gastrointestinal Disorders 3.6 (2020): 17-23.

Copyright

Copyright: © 2020 Pawar Abhimanrao Manikrao., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.