Carlos Juan Puig González, Griselda Navarro Figueredo, Zuzel Victoria Fito Paradelo, Giselle Ramos Martínez, Arlet García López and Otto Alemán Miranda*
Private Practice, USA
*Corresponding Author: Otto Alemán Miranda, Private Practice, USA.
Received: March 24, 2025; Published: April 03, 2025
Introduction: Odontogenic keratocysts are common benign lesions frequently associated with Gorlin-Goltz syndrome, known for their high recurrence risk following surgical treatment. Traditionally, these cysts have been managed through surgery; however, alternative therapeutic approaches, such as marsupialization combined with topical 5-fluorouracil (5-FU), have shown promising results. This combination therapy aims to reduce recurrence rates and improve long-term outcomes.
Objective: This study aims to evaluate the effectiveness of combining marsupialization with topical 5-FU in treating odontogenic keratocysts, particularly in patients diagnosed with Gorlin-Goltz syndrome.
Methods: Patients diagnosed with odontogenic keratocysts underwent marsupialization, followed by the application of a 5% 5-FU solution. The treatment was administered every 2-3 weeks over a period of 3-6 months. Clinical and radiographic assessments were conducted throughout the follow-up period to monitor the therapy’s effectiveness.
Results: The combined use of marsupialization and 5-FU demonstrated a significant reduction in recurrence rates, which ranged between 12% and 20%. Patients experienced minimal side effects, primarily local irritation or inflammation. Radiographic evaluations showed a decrease in the size of cystic cavities, indicating the therapy's efficacy.
Discussion: The combination of marsupialization and topical 5-FU offers a less invasive alternative to conventional surgical management of odontogenic keratocysts. This approach not only lowers recurrence rates but also shortens recovery time, making it a viable option for patients with Gorlin-Goltz syndrome. Although existing studies on this therapy remain limited, current findings suggest it is both safe and effective for managing odontogenic keratocysts.
Conclusions: Topical 5-FU application along with marsupialization presents a viable and effective alternative in the treatment of odontogenic keratocysts, with a low recurrence rate and minimal side effects. Its use as primary treatment is recommended, particularly in patients with Gorlin-Goltz syndrome. However, more controlled and randomized studies are needed to confirm these findings and establish definitive protocols.
Keywords: Gorlin-Goltz Syndrome; Clinical; Surgical
Citation: Otto Alemán Miranda., et al. “Gorlin-Goltz Syndrome: A Clinical and Surgical Approach" Acta Scientific Dental Sciences 9.5 (2025): 03-08.
Copyright: © 2025 Otto Alemán Miranda., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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