Nikolovski Bruno¹*, Radojkova Nikolovska Vera², Evrosimovska Biljana², Veleska Stevkovska Daniela² and Zafirova Biljana²

¹Faculty of medical sciences, University “Goce Delcev”, Stip, North Macedonia
²Faculty of dentistry, University “Ss. Cyril and Methodius”, Skopje, North Macedonia

*Corresponding Author: Nikolovski Bruno, Faculty of medical sciences, University “Goce Delcev”, Stip, North Macedonia.

Received: March 07, 2023; Published: March 30, 2023

Abstract

Oral cancer is a preventable disease. In 2021, the International Agency for Research on Cancer by World Health Organization, presents the number of 377713 new cases of oral cancer in 2020, making it the 16th most common malignant disease in the world, unfortunately with poor prognosis after treatment because of the late stage of the disease [1].

Aim: to explore the accuracy/efficacy, specificity and sensitivity, the positive and negative predicted values of the oral exfoliative cytology (brush biopsy) as a closest, but less invasive method to the tissue biopsy, respected as a gold standard in the diagnostic procedures.

Material and Methods: 60 patients divided into two study groups (30 of them with potentially malignant oral lesions and a second consisted of another 30 patients with previous oral malignant disease) were examined with brush biopsy and underwent to histopathological confirmation - tissue biopsy, selected under certain inclusion and exclusion criteria.

Results: Sensitivity of brush biopsy in the group of examinees with oral potentially malignant lesions is 100%, its specificity is 66.67%, the positive predictive value is 92.31% and the negative predictive value is 100%. The accuracy of the Brush biopsy method is 93.33%.

The sensitivity, in the group of patients with previous oral malignant disease, is 100%, specificity is 0%, the positive predictive value is 100% and the negative predictive value is 0%. The accuracy of this method is 100%.

Conclusion: The accuracy reaches a total value of 100% for the group with previous malignant lesions (relapse) and sets the thesis that brush biopsy as screening method for oral cancer or premalignant tissue changes is enough valuable for the patients with oral epithelial changes but may be combined with some other type of screening procedures, easy to perform and less invasive ones, in order to gain relevant results applicable in the everyday clinical practice.

Keywords: Subtotal Edentulousness; Axial Attachment; Cekapreci Line; Retention

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Citation

Citation: Nikolovski Bruno., et al. “Diagnostic and Prognostic Implications of the Oral Exfoliative Cytology in Oral precancer And Cancer Detection".Acta Scientific Dental Sciences 7.4 (2023): 129-136.

Copyright

Copyright: © 2023 Nikolovski Bruno., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.