Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 6 Issue 5

Alzheimer’s Neuropathology and its Possible Association with Periodontal Disease

Joana Braamcamp1*, Ricardo Faria-Almeida2 and Ana Cristina Braga3

1,2Faculty of Dentistry, University of Porto, Portugal
3Algoritmi Centre, University of Minho, Guimarães, Portugal

*Corresponding Author: Joana Braamcamp, Faculty of Dentistry, University of Porto, Portugal.

Received: March 25, 2022; Published: , 2022

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Abstract

Dementia is a severe public health issue that affects 47 million people in the world. The most common cause of dementia is Alzheimer’s disease, a progressive and irreversible neurodegenerative disorder that affects 60% to 80% of all patients diagnosed with dementia. Alzheimer’s disease is characterized by cortical and subcortical atrophy, neurofibrillary degeneration and accumulation of amyloid plaques in the brain, and it severely affects the quality of life of those who have it. The prevention of this disease involves identifying the risk factors that might activate or aggravate its neurodegenerative process. In this context, recent studies are evaluating a possible association between Alzheimer’s disease and periodontitis, in the sense that the induction of a chronic inflammatory state by the periodontal disease seems to develop or aggravate neuroinflammatory states that are typical of Alzheimer’s disease. The extensive study of bibliographic contents available at the PubMed platform, which resulted from a search with the terms “Alzheimer’s disease”, “dementia”, “systemic diseases”, “periodontitis”, “periodontal disease”, “amyloid plaques” and “prevention”, as well as the study of the books Clinical Periodontology and Implant Dentistry and Enfermedad de Alzheimer y otras Demencias, allowed to gather the latest information on a likely association between periodontal disease and Alzheimer’s disease. Considering the high prevalence of these conditions and the significance of Alzheimer’s as a Public health problem, it becomes imperative to study the modifiable risk factors associated with this serious and incurable condition.

Keywords: Alzheimer’s Disease; Dementia; Systemic Diseases; Periodontitis; Periodontal Disease; Amyloid Plaques; Prevention

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References

  1. Global action plan on the public health response to dementia 2017-2025 (2017).
  2. Gale SA., et al. “Dementia”. The American Journal of Medicine 10 (2018): 1161-1169.
  3. Aragón F., et al. “Oral health in Alzheimer's disease: a multicenter case-control study”. Clinical Oral Investigations9 (2018): 3061-3070.
  4. Braamcamp J and Faria-Almeida R. “Oral Health Approach to Patients with Dementia”. Acta Scientific Dental Sciences 9 (2021): 104-109.
  5. 2021 Alzheimer's disease facts and figures”. Alzheimers Dement 17.3 (2021): 327-406.
  6. Cerajewska TL., et al. “Periodontitis: a potencial risk factor for Alzheimer’s disease”. British Dental Journal 1 (2015): 29-34.
  7. Ishida N., et al. “Periodontitis induced by bacterial infection exacerbates features of Alzheimer’s disease in transgenic mice”. Mechanisms of Ageing and Development 3 (2017):
  8. Kamer AR., et al. “Periodontal disease as a possible cause for Alzheimer’s disease”. Periodontology 2000.83 (2019): 242-271.
  9. Fonseca R., et al. “Doença de Alzheimer como fator de risco à doença periodontal: uma revisão de literatura”. Brazillian Journal of Periodontology3 (2020): 121-126.
  10. World Health Organization. Oral Health Periodontal Country Profiles. Geneva, Switzerland: World Health Organization (2005).
  11. Navarro-Sanchez AB., et al. “Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis”. Journal of Clinical Periodontology 10 (2007): 835-843.
  12. Sanz M. “European workshop in periodontal health and cardiovascular disease”. European Heart Journal Supplements 12 (2010):
  13. Lockhart PB., et al. “Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?” Circulation 20 (2012): 2520-2544.
  14. Pinho MM., et al. “Periodontitis and atherosclerosis: an observational study”. Journal of Periodontal Research 4 (2013): 452-457.
  15. Nagpal R., et al. “The two-way association of periodontal infection with systemic disorders: an overview”. Mediators of Inflammation 2015 (2015):
  16. Jin L., et al. “Global burden of oral diseases: emerging concepts, management and interplay with systemic health”. Oral Diseases 7 (2016): 609-619.
  17. Tonetti MS., et al. “Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: a call for global action”. Journal of Clinical Periodontology 5 (2017): 456-462.
  18. Miricescu LD., et al. “Periodontal Disease and Systemic Health 6 (2019).
  19. Nazir M., et al. “Global Prevalence of Periodontal Disease and Lack of Its Surveillance”. The Scientific World Journal (2020): 2146160.
  20. Dik MG., et al. “APOE-epsilon4 is associated with memory decline in cognitively impaired elderly”. Neurology 7 (2000): 1492-1497.
  21. Alberca R and López S. “Enfermedade de Alzheimer y otras demencias (4th edition)”. Madrid: Editoral Médica Panamericana (2010).
  22. Kazui H., et al. “Differences of Behavioral and Psychological Symptoms of Dementia in Disease Severity in Four Major Dementias”. PloS one 8 (2016): e0161092.
  23. Chiricosta L., et al. “SARS-CoV-2 Exacerbates Beta-Amyloid Neurotoxicity, Inflammation and Oxidative Stress in Alzheimer's Disease Patients”. International Journal of Molecular Sciences 24 (2021): 13603.
  24. Xia X., et al. “COVID-19 and Alzheimer's disease: how one crisis worsens the other”. Translational Neurodegeneration 1 (2021): 15.
  25. Zhou Y., et al. “Alzheimer’s disease: Amyloid-based pathogenesis and potential therapies”. Cell Stress 7 (2018): 150-161.
  26. Paroni G., et al. “Understanding the Amyloid Hypothesis in Alzheimer's Disease”. Journal of Alzheimer's Disease 2 (2019): 493-510.
  27. Philstrom Bruce L., et al. “Periodontal diseases”. Lancet 366 (2015): 1809-1820.
  28. Lindhe J. “Tratado de Periodontia Clínica e Implantologia Oral. (5th edition) Rio de Janeiro: Guanabara Koogan (2018).
  29. Papapanou PN., et al. “Periodontitis: Consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions”. Journal of Clinical Periodontology 20 (2018): S162-S170.
  30. Alawaji YN., et al. “Periodontal disease prevalence, extent, and risk associations in untreated individuals”. Clinical and Experimental Dental Research 1 (2022): 380-394.
  31. Gaur S and Agnihotri R. “Alzheimer’s disease and chronic periodontitis: is there an association?” Geriatrics and Gerontology International 4 (2014): 391-404.
  32. Dioguardi M., et al. “The association between tooth loss and Alzheimer’s disease: a systematic review with meta-analysis of case control studies”. Dentistry Journal 49 (2019): 1-12.
  33. Femminella GD., et al. “Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume”. Neurology12 (2019): e1331-1343.
  34. Seulggie Choi MD., et al. “Association of chronic periodontitis on Alzheimer’s disease or vascular dementia”. Journal of the American Geriatrics Society 00 (2019): 1-6.
  35. Dioguardi M., et al. “The role of periodontitis and periodontal bacteria in the onset and progression of Alzheimer’s disease: a systematic review”. Journal of Clinical Medicine 495 (2020): 1-21.
  36. Leblhuber F., et al. “Knock-on effect of periodontitis to the pathogenesis of Alzheimer’s disease?” The Central European Journal of Medicine 132 (2020): 493-498.
  37. Liccardo D., et al. “Potencial bidirectional relationship between periodontitis and Alzheimer’s disease”. Frontiers in Physiology683 (2020): 1-13.
  38. Sadrameli M., et al. “Linking mechanisms of periodontitis to Alzheimer’s disease”. Current Opinion in Neurology 2 (2020): 230-238.
  39. Zhang Z., et al. “The role of porphyromonas gingivitis outer membrane vesicles in periodontal disease and related systemic diseases”. Frontiers in Cellular and Infection Microbiology585917 (2021): 1-12.
  40. “The Need for Early Detection and Treatment in Alzheimer’s Disease”. EBioMedicine 9 (2016): 1-2.
  41. Lee YT., et al. “Periodontitis as a Modifiable Risk Factor for Dementia: A Nationwide Population-Based Cohort Study”. Journal of the American Geriatrics Society2 (2017): 301-305.
  42. Gusman DJR., et al. “Periodontal disease severity in subjects with dementia: a systematic review and meta-analysis”. Archives of Gerontology and Geriatrics 76 (2018): 147-159.
  43. Mann J., et al. “Periodontal disease and its prevention, by traditional and new avenues (Review)”. Experimental and Therapeutic Medicine (2019).
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Citation

Citation: Joana Braamcamp et al. “Alzheimer’s Neuropathology and its Possible Association with Periodontal Disease". Acta Scientific Dental Sciences 6.5 (2022): 60-66.




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