Krishna Madhukumaran Pillai Sreekaladevi¹*, Shreya Kothari², Srikanth Tatikonda³, Vaishnavi Ramanan³, Valliammai Rajendran⁴ and Hridya Jayaprakash⁵

¹MDS, Ex-Post Graduate, Department of Oral Medicine and Maxillofacial Radiology, KVG Dental College and Hospital, Sulliya, India

*Corresponding Author: Krishna Madhukumaran Pillai Sreekaladevi, MDS, Ex-Post Graduate, Department of Oral Medicine and Maxillofacial Radiology, KVG Dental College and Hospital,Sulliya,India.

Received: November 22, 2021; Published: November 30, 2021

Abstract

  Platelet rich fibrin (PRF) is an autologous biomaterial with growth factors and cytokines entrapped in a fibrin matrix. In recent times it has been used in various disciplines in dentistry in a wide range of treatment modalities. An electronic literature research using the biomedical search engine ‘‘National Library of Medicine’’ (PubMed-MEDLINE) was performed. This narrative review aims to summarize the relevant literature regarding the technique of using PRF, its preparation, advantages, and disadvantages of using it in clinical situations. PRF alone or in combination with other biomaterials seems to have several advantages and indications both for medicine and dentistry, as it is a minimally invasive technique with reduced risks and satisfactory clinical results.

Keywords: Platelet; Healing; Fibrin

References

1. Duttenhoefer F., et al. “Follow-up of implant survival comparing ficoll and bone marrow aspirate concentrate methods for hard tissue regeneration with mesenchymal stem cells in humans”. Bioresearch Open Access2 (2014): 75-76.
2. Sakkas A., et al. “Autogenous bone grafts in oral implantology - is it still a ‘‘gold standard’’? A consecutive review”. International Journal of Implant Dentistry1 (2017): 23.
3. Singer AJ and Clark RA. “Cutaneous wound healing”. The New England Journal of Medicine10 (1999): 738-746.
4. Kanakamedala A., et al. “Treatment of a furcation defect with a combination of platelet-rich fibrin (PRF) and bone graft - a case report”. ENDO (London England) (2009): 127-135.
5. Gupta V., et al. “Regenerative Potential of Platelet Rich Fibrin in Dentistry: Literature Review”. Asian Journal of Oral Health and Allied Sciences6 (2011): 22-28.
6. Choukroun J., et al. “The PRF: an opportunity in implantology”. Pantodontid (2001): 55-62.
7. Malathi K., et al. “Periodontal regeneration of an intrabody osseous defect with combination of platelet rich fibrin and bovine derived demineralized bone matrix: A case report”. IOSR-JDMS2 (2013): 20-26.
8. Singh S., et al. “Application of PRF in surgical management of periapical lesions”. National Journal of Maxillofacial Surgery1 (2013): 94-99.
9. B. Jayalakshmi., et al. “Platelet-Rich Fibrin with β-Tricalcium Phosphate-A Novel Approach for Bone Augmentation in Chronic Periapical Lesion: A Case Report”. Case Reports in Dentistry (2012).
10. Shivashankar VY., et al. “Platelet Rich Fibrin in the revitalization of tooth with necrotic pulp and open apex”. Journal of Conservative Dentistry4 (2012): 395-398.
11. B. Geeta., et al. “A Natural Meliorate: Revolutionary Tissue Engineering in Endodontics”. Journal of Clinical and Diagnostic Research 7.11 (2013): 2644-2646.
12. Corso MD., et al. “Use of autologous leukocyte and platelet rich fibrin (L-PRF) membrane in post avulsion sites: an overview of Choukroun’s PRF”. The Journal of Implant and Advanced Clinical Dentistry (2010): 27-35.
13. Naik B., et al. “Role of Platelet rich fi brin in wound healing: A critical review”. Journal of Conservative Dentistry4 (2013): 284-293.
14. Qi Li., et al. “Platelet-Rich Fibrin Promotes Periodontal Regeneration and Enhances Alveolar Bone Augmentation”. Biomedical Research International (2013).
15. Munoz F., et al. “Use of leukocyte and platelet-rich fibrin (L-PRF) in periodontally accelerated osteogenic orthodontics (PAOO): clinical effects on edema and pain”. Journal of Clinical and Experimental Dentistry2 (2016): e119-e124.
16. Ghanaati S., et al. “Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells”. Journal of Oral Implantology6 (2014): 679-689.
17. Choukroun J and Ghanaati S. “Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells and platelets: first introduction of the low-speed centrifugation concept”. European Journal of Trauma and Emergency Surgery1 (2017): 87-95.
18. Al-maawi S., et al. “In vivo cellular reactions to different biomaterials-physiological and pathological aspects and their consequences”. Seminars in Immunology Journal 29 (2017): 49-61.
19. Esposito M., et al. “Treatment of periimplantitis: what interventions are effective? A Cochrane systematic review”. European Journal of Oral Implantology 5 (2012): S21-S41.
20. Ghanaati S., et al. “Fifteen Years of Platelet Rich Fibrin in Dentistry and Oral maxillofacial Surgery: How High is the Level of Scientific Evidence?”. Journal of Oral Implantology6 (2018): 471-492.

Citation

Citation: Krishna Madhukumaran Pillai Sreekaladevi., et al. “Current Trends in Application of Platelet Rich Fibrin". Acta Scientific Dental Sciences 5.12 (2021): 90-94.

Copyright

Copyright: © 2021 Krishna Madhukumaran Pillai Sreekaladevi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.