Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 5 Issue 12

“Fibromyalgia”- Diagnostic Concepts Rejuvenated: A Review

Aghina Pradeep1, Vathsala Naik2, Gaurav3*, Amandeep4, Sangeetha4 and Bhagya Balakrishnan5

1Final Year Postgraduate Student, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
2Professor and Head, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
3Assistant Professor, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
4Reader, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
5Post Graduate Student, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India

*Corresponding Author: Gaurav, Assistant Professor, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India.

Received: October 21, 2021; Published: November 16, 2021

Abstract

Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues. Although its etiopathogenesis and pathophysiology is known, their correlation as a diagnostic marker is poorly understood. As per WHO, it is estimated that up to three out of four people with the condition remain undiagnosed globally while the total prevalence stands approximately 0.20% amongst the Asian sub population. As there is still a diagnostic dilemma in case of FM, various diagnostic criteria have been put forward since years. In the scenario of unpredictable cascade of the malady, various new diagnostic aids are being tried world-wide based on various governing factors including “Oxidative stress”. This review describes the recent diagnostic criteria’s and recent diagnostic advancement based on various molecular parameters, the thought process enveloping around ‘Genetic’ (coding of protein back bone and numerous functional groups, genetic signatures in coding genes for HLA, MHC etc.) and ‘Metabolic’ (blood and urine) components. Although still in the phase of clinical trials, this unique technique of “Metabolic finger printing” holds a promising potential, not only towards turning a new leaf in the diagnostic approach of Fibromyalgia, but also determining a targeted therapy based treatment protocol, thereby bringing about a renaissance in this particular field.

Keywords: HLA; 5HT2A; Serotonin Receptors; LPC; Darapladib

References

  1. Galvez-Sánchez CM and Reyes Del Paso GA. “Diagnostic Criteria for Fibromyalgia: Critical Review and Future Perspectives”. Journal of Clinical Medicine 4 (2020): 1219.
  2. Hung CH., et al. “Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain”. Annals of the Rheumatic Diseases 12 (2020): 1644-1656.
  3. Hackshaw KV. “The Search for Biomarkers in Fibromyalgia”. Diagnostics (Basel)2 (2021): 156.
  4. Hackshaw KV., et al. “Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders”. Journal of Biological Chemistry 7 (2019): 2555-2568.
  5. Arnold LM., et al. “AAPT Diagnostic Criteria for Fibromyalgia”. Journal of Pain6 (2019): 611-628.
  6. Hackshaw KV., et al. “Metabolic fingerprinting for diagnosis of fibromyalgia and other rheumatologic disorders”. Journal of Biological Chemistry7 (2019): 2555-2568. Erratum in: J Biol Chem. 2020 Apr 24;295 (17): 5834.
  7. Häuser W and Fitzcharles MA. “Facts and myths pertaining to fibromyalgia”. Dialogues in Clinical Neuroscience 1 (2018): 53-62.
  8. Malatji BG., et al. “A diagnostic biomarker profile for fibromyalgia syndrome based on an NMR metabolomics study of selected patients and controls”. BMC Neurology1 (2017): 88.
  9. Üçeyler N., et al. “Ätiologie und Pathophysiologie des Fibromyalgiesyndroms : Aktualisierte Leitlinie 2017 und Übersicht von systematischen Übersichtsarbeiten sowie eine Übersicht über Studien zur Kleinfaserpathologie bei Subgruppen des FMS [Etiology and pathophysiology of fibromyalgia syndrome : Updated guidelines 2017, overview of systematic review articles and overview of studies on small fiber neuropathy in FMS subgroups]”. Schmerz3 (2017): 239-245.
  10. Clauw DJ. “Fibromyalgia: a clinical review”. JAMA15 (2014): 1547-1555.
  11. Clauw DJ. “Fibromyalgia: an overview”. American Journal of Medicine 122 (2009): S3-S13.

Citation

Citation: Gaurav., et al. ““Fibromyalgia”- Diagnostic Concepts Rejuvenated: A Reviews”. Acta Scientific Dental Sciences 5.12 (2021): 45-49.

Copyright

Copyright: © 2021 Gaurav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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