Aghina Pradeep¹, Vathsala Naik², Gaurav³*, Amandeep⁴, Sangeetha⁴ and Bhagya Balakrishnan⁵

¹Final Year Postgraduate Student, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
²Professor and Head, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
³Assistant Professor, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
⁴Reader, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India
⁵Post Graduate Student, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India

*Corresponding Author: Gaurav, Assistant Professor, Department of Oral Medicine and Radiology, Bangalore Institute of Dental Sciences and Hospital, Bangalore, India.

Received: October 21, 2021; Published: November 16, 2021

Abstract

Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep, memory and mood issues. Although its etiopathogenesis and pathophysiology is known, their correlation as a diagnostic marker is poorly understood. As per WHO, it is estimated that up to three out of four people with the condition remain undiagnosed globally while the total prevalence stands approximately 0.20% amongst the Asian sub population. As there is still a diagnostic dilemma in case of FM, various diagnostic criteria have been put forward since years. In the scenario of unpredictable cascade of the malady, various new diagnostic aids are being tried world-wide based on various governing factors including “Oxidative stress”. This review describes the recent diagnostic criteria’s and recent diagnostic advancement based on various molecular parameters, the thought process enveloping around ‘Genetic’ (coding of protein back bone and numerous functional groups, genetic signatures in coding genes for HLA, MHC etc.) and ‘Metabolic’ (blood and urine) components. Although still in the phase of clinical trials, this unique technique of “Metabolic finger printing” holds a promising potential, not only towards turning a new leaf in the diagnostic approach of Fibromyalgia, but also determining a targeted therapy based treatment protocol, thereby bringing about a renaissance in this particular field.

Keywords: HLA; 5HT2A; Serotonin Receptors; LPC; Darapladib

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Citation

Citation: Gaurav., et al. ““Fibromyalgia”- Diagnostic Concepts Rejuvenated: A Reviews”. Acta Scientific Dental Sciences 5.12 (2021): 45-49.

Copyright

Copyright: © 2021 Gaurav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.