Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Review Article Volume 5 Issue 12

Oral Submucous Firosis: An Update on Etiopathogenesis

Shriya Khera*

Senior Research Associate, Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, MAMC Campus, New Delhi, India

*Corresponding Author: Shriya Khera, Senior Research Associate, Oral Medicine and Radiology, Maulana Azad Institute of Dental Sciences, MAMC Campus, New Delhi, India.

Received: October 14, 2021; Published:00-00

Abstract

The theories related to development of oral submucous fibrosis (OSMF) has been multifactorial. Many etiological factors include the consumption of areca nut (supari), betel leaves (paan), tobacco and intake of spicy food which are commonly found in asian foods. Systemic causes like nutritional deficiency, genetic predisposition, autoimmunity, heat shock proteins have also been proposed as causative factors for OSMF. Albeit the extensive documented aetiological factors, the precise etiology is not yet known and no conclusive evidence has been linked to the development and progression of Oral Submucous Fibrosis. The present review aims to decipher the various etiological agents and decoding their role in pathogenesis and progression of Oral Submucous Fibrosis.

 

Keywords: Oral Submucous Fibrosis; Areca Nut; Pathogenesis; Review

References

  1. Rajendran R. “Oral submucous fibrosis: etiology, pathogenesis and future research”. Bulletin of World Health Organization 6 (1994): 985-996.
  2. Pindborg J and Sirsat S. “Oral submucous fibrosis”. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology 6 (1966): 764-779.
  3. Tilakaratne WM., et al. “Oral submucous fibrosis: Review on aetiology and pathogenesis”. Oral Oncology 42 (2006): 561-568.
  4. Salcedo R., et al. “Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: in vivo neovascularization induced by stromal-derived factor-1alpha”. The American Journal of Pathology 154 (1999): 1125-1135.
  5. Meghji S., et al. “An in vitro comparison of human fibroblasts from normal and oral submucous fibrosis tissue”. Archives of Oral Biology 32 (1987): 213-215.
  6. Utsunomiya H., et al. “Extracellular matrix remodeling in oral submucous fibrosis; its stage-specific modes revealed by immuno-histochemistry and in-situ hybridization”. Journal of Oral Pathology and Medicine 34 (2005): 498-507.
  7. Anila Namboodiripad PC. “Cystatin C. Its role in pathogenesis of OSMF”. Journal of Oral Biology and Craniofacial Research1 (2014): 42-46.
  8. Arakeri G., et al. “Oral submucous fibrosis: An update on current theories of pathogenesis”. Journal of Oral Pathology and Medicine6 (2017): 406-412.
  9. Nzegbule EC. “Assesment of copper levels in the soil and vegetation following repeated application of Bordeaux mixture to a cocoa plantation in south-eastern Nigeria”. Nigerian Agricultural Journal 34 (2003): 97-102.
  10. Arakeri G and Brennan PA. “Oral submucous fibrosis: an overview of the etiology, pathogenesis, classification, and principles of management”. British Journal of Oral and Maxillofacial Surgery 51 (2013): 587-593.
  11. Rajalalitha P and Vali S. “Molecular pathogenesis of oral submucous fibrosis- a collagen metabolic disorder”. Journal of Oral Pathology and Medicine 34 (2005): 321-328.
  12. Chang YC., et al. “Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis”. Oral Oncology 38 (2002): 425-430.
  13. Shieh DH., et al. “Effects of arecoline, safrole, and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan. Journal of Oral Pathology and Medicine 33 (2004): 581-587.
  14. Wang CC., et al. “Areca nut extract suppresses T-cell activation and interferon-c production via the induction of oxidative stress”. Food and Chemical Toxicology 45 (2007): 1410-1418.
  15. Jeng JH., et al. “Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives”. Oral Oncology 37 (2001): 477-492.
  16. Aziz SR. “Oral submucous fibrosis: case report and review of diagnosis and treatment”. Journal of Oral and Maxillofacial Surgery11 (2008): 2386-2389.
  17. Haque MF., et al. “Oral submucous fibrosis patients have altered levels of cytokine production”. Journal of Oral Pathology and Medicine 29 (2000): 123-128.
  18. Haque MF., et al. “Immunolocalization of cytokines and growth factors in oral submucous fibrosis”. Cytokine 10 (1998): 713-719.
  19. De Waal J., et al. “The fibroblast population in Oral submucous fibrosis”. Journal of Oral Pathology and Medicine 26 (1997): 69-74.
  20. Balaram P., et al. “Immunology of premalignant and malignant conditions of the oral cavity. Part II. Circulating immune complexes”. Journal of Oral Pathology and Medicine 16 (1987): 389-391.
  21. Remani P., et al. “Circulating immune complexes as an immunological marker in premalignant and malignant lesions of the oral cavity”. Cancer Letters 40 (1988): 185-191.
  22. Dyavanagoudar S N. “Oral Submucous Fibrosis: Review on Etiopathogenesis”. Journal Cancer Science and Theraphy 1 (2009): 72-77.
  23. Jayanthi V., et al. “Oral submucosal fibrosis a preventable disease”. Gut 33 (1992): 4-6.
  24. Khanna SS and Karjodkar FR. “Circulating Immune Complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer: A randomised, controlled clinical trial”. Head and Face Medicine 2 (2006): 33.
  25. Anuradha CD and Devi CS. “Serum protein, ascorbic acid and iron and tissue collagen in Oral submucous fibrosis. - a preliminary study”. Indian Journal of Medical Research 98 (1993): 147-151.
  26. Taneja L., et al. “Haemoglobin levels in patients with oral submucous fibrosis”. Journal of Indian Academy of Oral Medicine and Radiology 19 (2007): 329-333.

Citation

Citation: Shriya Khera. “Oral Submucous Firosis: An Update on Etiopathogenesis". Acta Scientific Dental Sciences 5.12 (2021): 29-32.

Copyright

Copyright: © 2021 Shriya Khera. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days

Indexed In



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is November 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US









ff

© 2024 Acta Scientific, All rights reserved.