Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Research Article Volume 5 Issue 12

Comparison of the Efficacy of Prophylactic Intraligamentary Injection of Piroxicam Versus Mepivacaine for Management of Post-endodontic Pain in Posterior Teeth: (Double Blind Randomized Clinical Trial)

Hend Hassan Swellam1*, Hebatallah Mohamed Elfar2 and Sherif Adel El khodary3

1Master of Endodontics, Faculty of Dentistry, Cairo University, Egypt
2Professor of Endodontics, Faculty of Dentistry, Cairo University, Egypt
3Associate Professor of Endodontics, Faculty of Dentistry, Cairo University, Egypt

*Corresponding Author: Hend Hassan Swellam, Master of Endodontics, Faculty of Dentistry, Cairo University, Egypt.

Received: September 24, 2021; Published: November 10, 2021

Abstract

The aim of this research was to evaluate the effect of piroxicam (feldene) on reducing the pain after single visit endodontic treatment, a non-selective non-steroidal anti-inflammatory drug. Twenty-six patients, aged between 25 and 50 years with irreversible pulpitis and symptomatic apical periodontitis in mandibular molar teeth were randomly divided into two groups. The experimental group received intraligamentary injections totaling 0.4 mL of piroxicam, while the control group received the same amount of intraligamentary mepivacaine.

Single visit root canal treatment was performed by a single endodontist. Numeric Rating Scale was used to record pain before treatment and at 4, 8, 12, 24 and 48 h postoperatively. The decrease in the intensity of post-treatment pain between the two groups was statistically significant. Intraligamentary injection of piroxicam can be considered an effective method for decreasing post-endodontic pain.

Keywords: Post-endodontic Pain; Mepivacaine; Teeth

References

  1. Nazaroglou I., et al. “Postoperative pain in dentistry: a review”. Surgery Journal 3 (2008): 96-103.
  2. Ehrmann EH., et al. “Flare-ups in endodontics and their relationship to various medicaments”. Australian Endodontic Journal 33 (2007): 119-130.
  3. Kohli D., et al. “Postendodontic pain: a practical approach to diagnosis and management”. Quintessence International 5 (2021): 384-392.
  4. Shirvani A., et al. “The efficacy of non-narcotic analgesics on post-operative endodontic pain: A systematic review and meta-analysis”. Journal of Oral Rehabilitation 44 (2017): 709-721.
  5. Smridhi Bhanot., et al. “Antibiotics and Analgesics in Endodontics-A Review”. IAR Journal of Medical Sciences 1 (2021): 13-23.
  6. Sadaf D and Ahmad MZ. “Factors Associated with Postoperative Pain in Endodontic Therapy”. IJBS 4 (2014): 243-247.
  7. Mohammadi Z., et al. “Pharmacological strategies to control post-operative endodontic pain”. Dental Research Journal 4 (2007): 61-68.
  8. Elzaki WM., et al. “Double-blind Randomized Placebo-controlled Clinical Trial of Efficiency of Nonsteroidal Anti-inflammatory Drugs in the Control of Post-endodontic Pain”. Journal of Endodontics6 (2016): 835-842.
  9. Ong KS and Seymour RA. “Maximizing the safety of Nonsteroidal Antii inflammatory Drug Use for Postoperative Dental Pain: An Evidence-based Approach”. Anesthesia Progress 5 (2003): 62-74.
  10. Mohammadi Z., et al. “Pharmacological Control post-operative Endodontic Pain”. Dental Research Journal 2 (2007): 61-68.
  11. O’Brien TP., et al. “Effect of A Non-Steroidal Anti-Inflammatory Drug on Tissue Levels of Immunoreactive Prostaglandin E2, Immunoreactive Leukotriene, and pain after Periodontal Surgery”. Journal of Periodontology 67 (1996): 1307-1316.
  12. Brunton LL., et al. “Goodman and Gilman’s The Pharmacological Basis of Therapeutics”. 11th ed. NewYork: McGraw Hill, Medical Publishing Devision (2006).
  13. Schulz KF., et al. “CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials”. BMC Medicine 8 (2010): 18.
  14. Mokhtari F., et al. “Effect of Premedication with Indomethacin and Ibuprofen on Postoperative Endodontic Pain: A Clinical Trial”. Iranian Endodontic Journal 1 (2016): 57-62.
  15. Ramesh S. “Pain management in endodontics”. Journal of Pain and Symptom Management 4 (2013): 281-289.
  16. Joshi N., et al. “Comparative evaluation of the efficacy of two modes of delivery of Piroxicam for the management of postendodontic pain: A randomized control trial”. Journal of Conservative Dentistry 4 (2016): 301-305.
  17. Hargreaves KM., et al. “Pharmacologic Management of Endodontic Pain”. In: Ingle JI, Backland LK, Baumgartner JC. Endodontics. 6th ed. Hamilton: Ontario, (2008): 713-736.
  18. Khan AA and Dionne RA. “Cox-2 inhibitors for endodontic pain”. Endodontic Topics 3 (2002): 31-40.
  19. Armando Maccango MD., et al. “Double-blind controlled clinical trial of oral s-adenosylmethionine versus piroxicam in knee osteoarthritis”. American Journal of Medicine 5 (1987): 72-77.
  20. Adnan Atbaei and Nazanin Mortazavi. “Prophylactic intraligamentary injection of piroxicam (feldene) for management of post endodontic pain in molar teeth with irreversible pulpitis”. Australian Endodontic Journal 1 (2012): 31-35.
  21. Law AS., et al. “Predicting severe pain after root canal therapy in the National Dental PBRN”. Journal of Dental Research 94 (2015): 37S-43S.
  22. Sipavičiūtė E and Manelienė R. “Pain and flare-up after endodontic treatment procedures”. Stomatologija Baltic Dental and Maxillofacial Journal1 (2014): 25-30.
  23. Gill GS., et al. “Single Versus Multi-visit Endodontic Treatment of Teeth with Apical Periodontitis”. Annals of Medical and Health Science Research 1 (2016): 19-26.
  24. Kaufman E., et al. “Intraligamentary anaesthesia: a clinical study”. Journal of Prosthetic Dentistry 49 (1983): 337-339.
  25. SUBHAN ZAINAB., et al. “Comparison of Prophylactic Intraligamentary Injection of Piroxicam and Lignocaine for Management of Postoperative Endodontic Pain”. Pakistan Oral and Dental Journal 3 (2016): 480-483.
  26. Jorge Paredes Vieyra., et al. “The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo on Postoperative Pain in Teeth with Irreversible Pulpitis and Apical Periodontitis”. Oral Health and Dentistry4 (2018): 410-420.
  27. Raksh Bhat., et al. “Evaluation of the efficiency of Intraligamentary Diclofenac Sodium in reducing postoperative endodontic pain in patients with irreversible pulpitis”. International Research Journal of Pharmacy 4 (2013): 237-239.

Citation

Citation: Hend Hassan Swellam., et al. “Comparison of the Efficacy of Prophylactic Intraligamentary Injection of Piroxicam Versus Mepivacaine for Management of Post-endodontic Pain in Posterior Teeth: (Double Blind Randomized Clinical Trial)". Acta Scientific Dental Sciences 5.12 (2021): 08-15.

Copyright

Copyright: © 2021 Hend Hassan Swellam., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days

Indexed In



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US