Introduction

The odontogenic keratocyst also called epidermoid cyst, was first described by Philipsen in 1956; it develops at the expense of remnants of the odontogenic epithelium included in the maxillae. It is characterized by a large keratinization of its squamous border, aggressive growth and a strong propensity for recidivism. After the root cyst and the follicular cyst, the odontogenic keratocyst is the most common cyst of the maxillae.

References

1. Noorieh Sharifi-Sistani., et al. “Immunohistochemical Comparison of the Expressionof p53 and MDM2 Proteins in Ameloblastomasand Keratocystic Odontogenic Tumors”. Journal of Craniofacial Surgery 22 (2011): 1652-1656.
2. Ogden GR., et al. “Assessment of p53 protein expression in normal, benign, and malignant oral mucosa”. Journal of Pathology 166 (1992): 389-394.
3. Slootweg PJ. “P53 protein and Ki-67 reactivity in epithelial odontogenic lesions. An immunohistochemical study”. Journal of Oral Pathology and Medicine 24 (1995): 393-397.
4. Li TJ., et al. “Epithelial cell proliferation in odontogenic keratocysts: a comparative immunocytochemical study of Ki67 in simple, recurrent and basal cell naevus syndrome (BCNS) Yassociated lesions”. Journal of Oral Pathology and Medicine 24 (1995): 221-226.
5. Kichi E., et al. “Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts”. Journal of Oral Pathology and Medicine 34 (2005): 280-286.
6. Piattelli A., et al. “P53 protein expression in odontogenic cysts”. Journal of Endodontics 27 (2001): 459-461.
7. Carvalhais J., et al. “P53 and MDM2 expression in odontogenic cysts and tumours”. Oral Disease 5 (1999): 218-222.
8. de Oliveira MG., et al. “Immunohistochemical analysis of the patterns of p53 and PCNA expression in odontogenic cystic lesions”. Medicina Oral, Patologia Oral y Cirugia Bucal 13 (2008): E275-E280
9. Gurgel CA., et al. “Expression of Ki-67, p53 and p63 proteins in keratocyst odontogenic tumours: an immunohistochemical study”. Journal of Molecular Histology 39 (2008): 311-316.
10. Maryam Seyedmajidi., et al. “p53 and PCNA Expression in Keratocystic Odontogenic Tumors Compared with Selected Odontogenic Cysts”. IJMCM Autumn4 (2013).
11. Bath-Balogh M and Fehrenbach MJ. “Illustrated dental embryology, histology and anatomy”. 3rd edition, Elsevier Saunders (2011): 50-61.
12. Borda A. “Curs de Histologie pentru Facultatea de Stomatologie”. Vol. II, Universitatea de Medicină şi Farmacie din Tîrgu Mureş (2000): 40-90.
13. Curran AE., et al. “Pathologically significant pericoronal lesions in adults: histopathologic evaluation”. Journal of Oral and Maxillofacial Surgery6 (2002): 613-617.
14. Adina-Simona Coşarcă., et al. “The evaluation of Ki67, p53, MCM3 and PCNA immunoexpressions at the level of the dental follicle of impacted teeth, dentigerous cysts and keratocystic odontogenic tumors”. Romanian Journal of Morphology and Embryology 2 (2016): 407-412.
15. Shear M. “The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies”. Oral Oncology4 (2002): 323-331.
16. Nafarzadeh S., et al. “A comparative study of PCNA and Ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma”. International Journal of Molecular and Cellular Medicine 1 (2013): 27-33.
17. June-Ho Byun., et al. “Expansile keratocystic odontogenic tumor in the maxilla: immunohistochemical studies and review of literature”. Journal of the Korean Association of Oral and Maxillofacial Surgeon 39 (2013): 182-187.
18. Lo Muzio L., et al. “p63 expression in odontogenic cysts”. International Journal of Oral and Maxillofacial Surgery 34 (2005): 668-673.
19. Gadbail AR., et al. “Co-expression of Ki-67 and p53 protein in ameloblastoma and keratocystic odontogenic tumor”. Acta Odontologica Scandinavica 70 (2012): 529-535.
20. Seyed Mohammad RAZAVI., et al. “Investigation of clinicopathological parameters alongside with p53 expression in primary and recurrent keratocystic odontogenic tumours”. Malaysian Journal of Pathology2 (2014): 105-113.
21. Kuroyanagi N., et al. “Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinicopathologic and immunohistochemical findings in cysts treated by enucleation”. Journal of Oral Pathology and Medicine 38 (2009): 386-392.
22. de Paula AM., et al. “Cell proliferation markers in the odontogenic keratocyst: effect of inflammation”. Journal of Oral Pathology and Medicine 29 (2000): 477-482.
23. Kaplan I and Hirshberg A. “The correlation between epithelial cell proliferation and inflammation in odontogenic keratocyst”. Oral Oncology 40 (2004): 985-991.
24. Philipsen HP. “Om keratocyster (kolesteatom) I kaeberne”. Tandlaege bladet 60 (1956): 963-981.
25. Ahlem Beltaief., et al. “Etude immunohistochimique des facteurs de la prolifération (Ki67, PCNA) et de l’apoptose (P53) sur 40 kératokystes odontogénes”. Medecine Buccale Chirurgie Buccale 18 (2012): 17-22.
26. Lombardi T., et al. “p53 immunohistochemistry of odontogenic keratocysts in relation to recurrence, basal-cell budding and basal-cell naevus syndrome”. Archives of Oral Biology12 (1995): 1081-1084.
27. Li TJ., et al. “p53 expression in odontogenic keratocyst epithelium”. Journal of Oral Pathology and Medicine5 (1996): 249-255.
28. Neville WB., et al. “Oral and maxillofacial pathology”. 3rd edition, Elsevier Saunders, Philadelphia (2008).

Citation

Citation: M Bousserouit and S Chbicheb. “Evaluation of P53 in the Expression of Odontogenic Keratocysts”. Acta Scientific Dental Sciences 5.2 (2021): 105-111.

Copyright

Copyright: © 2021 M Bousserouit and S Chbicheb. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.