Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Research Article Volume 5 Issue 2

Radicular Cyst with Associated Extramedullary Hematopoiesis: A Previously Undescribed Phenomenon. Literature Review and Report of a Case

Toferer Astrid1*, Truschnegg Astrid2, Beham-Schmid Christine3 and Beham Alfred4*

1Division of Oral and Maxillofacial Surgery, Medical University of Graz, Austria
2Lecturer, Division of Dental Medicine and Oral Health, Medical University of Graz, Austria
3Professor, Lecturer, Diagnostic and Research Center for Molecular Bio Medicine, Diagnostic and Research Institute of Pathology, Medical University of Graz, Austria
4 Retired Professor, Medical University of Graz, Austria

*Corresponding Author: Toferer Astrid, Division of Oral and Maxillofacial Surgery, Medical University of Graz, Austria.

Received: December 02, 2020; Published: January 11, 2021

×

Abstract

Objective: The aim of this paper is to present the first case of a radicular cyst, with associated extramedullary hematopoiesis in a 57- year- old male patient. Prompted by this unique finding, we reviewed the existing literature systematically to identify extramedullary hematopoiesis in the maxillofacial area.

Study Design: A review of the evidence was conducted using PubMed/MEDLINE and Google Scholar. The following key words were applied: “extramedullary hematopoiesis” OR “extramedullary haematopoiesis” AND “maxillofacial”, OR “jaw”, OR “sinonasal tract”, OR “paranasal sinus”, OR “sinus”.

Results: The electronic search revealed 23 published cases; all relevant reported parameters were listed in tabular form. All cases were associated with a hematological disease, which is in contrast to our case. 11 years of follow up care revealed no systemic hematologic disorder. In view of this main difference, our case is the first described radicular cyst with extramedullary hematopoiesis. Histologic illustrations are presented, hematopoietic cells including erythrocytes, myeloid cells and megakaryocytes were characterized according to their lineage by immunohistochemistry.

Conclusions: Extramedullary hematopoiesis in the maxillofacial area can be found in patients without underlying hematologic disease. Each radicular cyst should be examined histopathologically, due to the possibility of unexpected morphological findings.

Keywords: Extramedullary Hematopoiesis; Radicular Cyst; Immunohistochemistry; Mandible

×

References

  1. Johnson NR., et al. “Frequency of odontogenic cysts and tumors: a systematic review”. Journal of Investigative and Clinical Dentistry1 (2014): 9-14.
  2. Speight P and Tekkesin MS. “WHO Classification of Head and Neck Tumors”. Lyon: IARC (2017): 205-260.
  3. Tavares DP., et al. “Clinical and radiological analysis of a series of periapical cysts and periapical granulomas diagnosed in a Brazilian population”. Journal of Clinical and Experimental Dentistry1 (2017): e129-135.
  4. Chen JH., et al. “Clinicopathological analysis of radicular cysts of the jawbone in a population of southern Taiwanese patients”. Journal of Medical Sciences4 (2018): 249-254.
  5. Deepthi PV., et al. “A study of 1177 odontogenic lesions in a South Kerala population”. Journal of Oral and Maxillofacial Pathology (2016).
  6. Santos LCS., et al. “Histopathological study of radicular cysts diagnosed in a Brazilian population”. Brazilian Dental Journal6 (2011).
  7. Kumar M., et al. “Rare presentation of radicular cyst with sebaceous differentiation”. Saudi Journal for Dental Research 2 (2014): 120-122.
  8. Chrcanovic BR and Gomez RS. “Squamous odontogenic tumor and squamous odontogenic tumor-like proliferations in odontogenic cysts: an updated analysis of 170 cases reported in the literature”. Journal of Cranio-Maxillofacial Surgery 3 (2018): 504-510.
  9. Kün-Darbois JD., et al. “In situ squamous cell carcinoma arising in a mandibular radicular cyst”. European Annals of Otorhinolaryngology, Head and Neck Diseases5 (2015): 305-306.
  10. Borras-Ferreres J., et al. “Malignant changes developing from odontogenic cysts: a systematic review”. Journal of Clinical and Experimental Dentistry (2016).
  11. Economopoulou P and Goutzanis L. “Focal giant cell lesion in the wall of a radicular cyst”. 2 (2016): 1-5.
  12. Noda A., et al. “A bilocular radicular cyst in the mandible with tooth structure components inside”. Case Reports in Dentistry (2019).
  13. Shivare P., et al. “Multilocular radicular cyst – a common pathology with uncommon radiological appearance”. Journal of Clinical and Diagnostic Research (2016).
  14. Andreou J., et al. “Bone marrow hyperplasia of the maxillary sinuses in β – thalassemia”. Journal of Computer Assisted Tomography (1984).
  15. Fernandez M., et al. “Maxillary sinus marrow hyperplasia in sickle cell anemia”. Pediatric Radiology (1995).
  16. Joseph M., et al. “Hematopoietic tissue presenting as a sphenoid sinus mass: case report”. Neuroradiology (2000).
  17. Vargas H., et al. “Unusual paranasal sinus tumor in two patients with common nasal complaints”. Ear Nose and Throat Journal10 (2001): 724-726.
  18. Reed Kearny P and Nasser A. “Pathology quiz case 2. Extramedullary hematopoeisis (EMH) of paranasal sinuses”. Archives of Otolaryngology - Head and Neck Surgery 1 (2002): 78-79.
  19. Rizzo L., et al. “Extramedullary hematopoiesis: unusual meningeal and paranasal sinuses presentation in paget, Case report”. Radiologia Medica 4 (2003): 376-381.
  20. Brennan LV., et al. “Extramedullary hematopoiesis occurring as a nasal polyp in a man with a myeloproliferative disorder”. Ear Nose and Throat Journal (2004).
  21. Collins WO., et al. “Extramedullary hematopoiesis of the paranasal sinuses in sickle cell disease”. Otolaryngology–Head and Neck Surgery (2005).
  22. Baskurt E., et al. “Extramedullary hematopoiesis involving the bilateral lacrimal fossae”. American Journal of Neuroradiology (2006).
  23. Ittipunkul N., et al. “Extra-medullary hematopoiesis causing bilateral optic atrophy in beta thalassemia / Hb E disease”. Journal of the Medical Association of Thailand 4 (2007): 809-812.
  24. Santonja C., et al. “Extramedullary hematopoiesis within endothelial papillary hyperplasia (Masson`s pseudoangiosarcoma) of the tongue”. Medicina Oral, Patología Oral y Cirugía Bucal8 (2007).
  25. Kulendra K., et al. “Unusual clivus lesion demonstrating extramedullary haematopoiesis: case report”. Journal of laryngology and Otology (2009).
  26. Stamataki S., et al. “Extramedullary hematopoiesis in the maxillary sinus”. International Journal of Pediatric Otolaryngology Extra (2009).
  27. Bizzoni A., et al. “Extramedullary hematopoiesis: a rare occurrence in the sinonasal tract”. Auris Nasus Larynx (2010).
  28. Hoskins Dorton L and Mims JW. “Extramedullary hematopoiesis of the maxilla in beta-thalassemia”. Otolaryngology–Head and Neck Surgery (2011).
  29. Sklar M., et al. “Radiographic features in a rare case of sphenoid sinus extramedullary hematopoiesis in sickle cell disease”. International Journal of Pediatric Otorhinolarygology (2013).
  30. Özgür A., et al. “Extramedullary hematopoiesis of the paranasal sinuses associated with moyamoya syndrome in sickle cell disease”. International Journal of Pediatric Otolaryngology (2014).
  31. Reiersen DA., et al. “Maxillofacial extramedullary hematopoiesis in a child with sickle cell presenting as a bilateral periorbital cellulitis”. International Journal of Pediatric Otorhinolaryngology (2014).
  32. Vanikieti K., et al. “Compressive optic neuropathy in thalassemia: a rare ophthalmic consequence of extramedullary hematopoiesis”. Journal of Clinical and Experimental Ophthalmology (2016).
  33. Densky J., et al. “Extramedullary hematopoiesis of the sphenoid sinus associated with hereditary spherocytosis: a case report”. International Journal of Pediatric Otorhinolaryngology (2018).
  34. Caiado R., et al. “Extra-medullary haematopoiesis in the nose – a rare case”. Annals of Otology, Rhinology and Laryngology1 (2017): 1157.
  35. Clark C., et al. “Extramedullary hematopoiesis in the sinonasal cavity: a case report and review of the literature”. Allergy and Rhinology (2020).
  36. Yamamoto K., et al. “Extramedullary hematopoiesis: Elucidating the function of the hematopoietic stem cell niche (Review)”. Molecular Medicine Reports (2016).
  37. Fan N., et al. “Extramedullary hematopoiesis in the absence of myeloproliferative neoplasm: Mayo Clinic series of 309 patients”. Blood Cancer Journal (2018).
  38. Bao Y., et al. “Extramedullary hematopoiesis secondary to malignant solid tumors: a case report and literature review”. Cancer Management Research (2018).
  39. Schmid C., et al. “Hematopoiesis in a degenerative uterine leiomyoma”. Archives of Gynecology and Obstetrics (1990).
  40. Singh P., et al. “Endometrial osseous metaplasia and mature bone formation with extramedullary hematopoiesis”. Journal of Human Reproductive Sciences1 (2011): 56-57.
  41. Hanamornroongruang S., et al. “Extramedullary hematopoiesis in the uterine cervix associated with tissue repair”. Case Reports in Obstetrics and Gynecology (2013).
  42. Kaddu S., et al. “Extramedullary hematopoiesis in pilomatricomas”. American Journal of Dermatopathology (1995).
  43. Baldovini C., et al. “Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in trichilemmal cyst”. American Journal of Dermatopathology (2014).
  44.  
×

Citation

Citation: Toferer Astrid., et al. “Radicular Cyst with Associated Extramedullary Hematopoiesis: A Previously Undescribed Phenomenon. Literature Review and Report of a Case”. Acta Scientific Dental Sciences 5.2 (2021): 37-44.




Metrics

Acceptance rate33%
Acceptance to publication20-30 days
Impact Factor0.614

Indexed In



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is September 30, 2021.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US






    Warning: include(footer.php): failed to open stream: No such file or directory in /home/emailacta1/public_html/ASDS/ASDS-05-1019.php on line 313

    Warning: include(): Failed opening 'footer.php' for inclusion (include_path='.:/opt/alt/php56/usr/share/pear:/opt/alt/php56/usr/share/php') in /home/emailacta1/public_html/ASDS/ASDS-05-1019.php on line 313