Acta Scientific Dental Sciences (ASDS)(ISSN: 2581-4893)

Research Article Volume 5 Issue 2

Radicular Cyst with Associated Extramedullary Hematopoiesis: A Previously Undescribed Phenomenon. Literature Review and Report of a Case

Toferer Astrid1*, Truschnegg Astrid2, Beham-Schmid Christine3 and Beham Alfred4*

1Division of Oral and Maxillofacial Surgery, Medical University of Graz, Austria
2Lecturer, Division of Dental Medicine and Oral Health, Medical University of Graz, Austria
3Professor, Lecturer, Diagnostic and Research Center for Molecular Bio Medicine, Diagnostic and Research Institute of Pathology, Medical University of Graz, Austria
4 Retired Professor, Medical University of Graz, Austria

*Corresponding Author: Toferer Astrid, Division of Oral and Maxillofacial Surgery, Medical University of Graz, Austria.

Received: December 02, 2020; Published: January 11, 2021



Objective: The aim of this paper is to present the first case of a radicular cyst, with associated extramedullary hematopoiesis in a 57- year- old male patient. Prompted by this unique finding, we reviewed the existing literature systematically to identify extramedullary hematopoiesis in the maxillofacial area.

Study Design: A review of the evidence was conducted using PubMed/MEDLINE and Google Scholar. The following key words were applied: “extramedullary hematopoiesis” OR “extramedullary haematopoiesis” AND “maxillofacial”, OR “jaw”, OR “sinonasal tract”, OR “paranasal sinus”, OR “sinus”.

Results: The electronic search revealed 23 published cases; all relevant reported parameters were listed in tabular form. All cases were associated with a hematological disease, which is in contrast to our case. 11 years of follow up care revealed no systemic hematologic disorder. In view of this main difference, our case is the first described radicular cyst with extramedullary hematopoiesis. Histologic illustrations are presented, hematopoietic cells including erythrocytes, myeloid cells and megakaryocytes were characterized according to their lineage by immunohistochemistry.

Conclusions: Extramedullary hematopoiesis in the maxillofacial area can be found in patients without underlying hematologic disease. Each radicular cyst should be examined histopathologically, due to the possibility of unexpected morphological findings.

Keywords: Extramedullary Hematopoiesis; Radicular Cyst; Immunohistochemistry; Mandible



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Citation: Toferer Astrid., et al. “Radicular Cyst with Associated Extramedullary Hematopoiesis: A Previously Undescribed Phenomenon. Literature Review and Report of a Case”. Acta Scientific Dental Sciences 5.2 (2021): 37-44.


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