SJ Gopu¹*, Sumesh Raj² and Manoj P³

¹General Medicine (2nd Year Junior Resident), At Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Trivandrum (SGMC), Kerala University of Health Sciences, India
²Professor, Department of General Medicine, Sree Gokulam Medical College (SGMC), India
³Senior Consultant, Neurologist, Sree Gokulam Medical College (SGMC), India

*Corresponding Author: SJ Gopu, General Medicine (2nd Year Junior Resident), At Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Trivandrum (SGMC), Kerala University of Health Sciences, India.

Received: May 14, 2025; Published: June 03, 2025

Abstract

Dermatomyositis is an idiopathic inflammatory myopathy typically characterized by proximal muscle weakness, elevated muscle enzymes, and characteristic skin manifestations. We report a case of a 64-year-old male who presented with classic clinical features but had normal serum creatine phosphokinase (CPK) levels and elevated aldolase, posing a diagnostic challenge. MRI findings, muscle biopsy and serologic test confirmed dermatomyositis with borderline positivity for Anti-PL7 antibodies. This case highlights the importance of a comprehensive diagnostic approach in inflammatory myopathies

Keywords: Dermatomyositis; Aldolase; Anti-PL7 Antibody; Normal CPK; Muscle Biopsy; MRI

References

1. Dalakas MC. “Inflammatory muscle diseases”. The New England Journal of Medicine18 (2015): 1732-1747.
2. Mammen AL. “Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis”. Nature Reviews Neurology 6 (2011): 343-354.
3. Sontheimer RD. “Dermatomyositis : An overview of recent progress with emphasis on dermatological aspects”. Dermatology Clinics3 (2002): 387-408.

Citation

Citation: SJ Gopu., et al. “Dermatomyositis with Normal CPK, Elevated Aldolase, and Borderline Anti-PL7 Antibody Positivity: A Case Report". Acta Scientific Clinical Case Reports 6.7 (2025): 03-06.

Copyright

Copyright: © 2025 SJ Gopu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.