Four Cases of Cholangiopathy Post-COVID
Matheus Rocha de Seixas Nogueira and Liliana Sampaio Costa Mendes*
Department of Hepatology, Base Hospital of the Federal District - Institute of Strategic
Health Management of the Federal District (HBDF/IGES-DF), Higher School of Health
Sciences - Department of State Health of Federal District (ESCS - SES DF), Brazil
*Corresponding Author: Liliana Sampaio Costa Mendes, Department of Hepatology, Base Hospital of the Federal District - Institute of Strategic
Health Management of the Federal District (HBDF/IGES-DF), Higher School of Health
Sciences - Department of State Health of Federal District (ESCS - SES DF), Brazil.
Received:
December 12, 2023; Published: January 03, 2024
Abstract
The article explores the emergence of cholangiopathy as a post-COVID-19 complication, presenting a detailed analysis of four cases observed in tertiary hospitals in Brazil. The study focuses on patients who developed cholestatic disorders following severe COVID-19, revealing clinical, laboratory, and radiological manifestations. The patients, predominantly male, experienced prolonged hospitalization, mechanical ventilation, and hemodynamic support during their initial COVID-19 diagnosis. The cholangiopathy cases exhibited alterations in canalicular enzymes, liver transaminases, and bilirubins, with a radiological pattern resembling Primary Sclerosing Cholangitis. The findings contribute to the growing body of literature on this novel complication, emphasizing the importance of further research and understanding in the medical community.
Keywords: COVID-19; Brazil; SARS-CoV-2
References
- Wang C., et al. “A novel coronavirus outbreak of global health concern”. Lancet 10223 (2020): 470-473.
- Gorbalenya AE., et al. “The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2”. Nature Microbiology4 (2020): 536-544.
- Sharma A., et al. “Liver disease and outcomes among COVID-19 hospitalized patients - A systematic review and meta-analysis”. Annals of Hepatology 21 (2021): 100273.
- Roth NC., et al. “Post-COVID-19 Cholangiopathy: A Novel Entity”. American Journal of Gastroenterology5 (2021): 1077- 1082.
- Yanny B., et al. “Post-COVID-19 Cholangiopathy: A Systematic Review”. Journal of Clinical and Experimental Hepatology3 (2023): 489-499.
- Rasheed MA., et al. “Post-COVID-19 cholangiopathy: Systematic review”. World Journal of Methodology4 (2023): 296-322.
- Faruqui S., et al. “Cholangiopathy After Severe COVID-19: Clinical Features and Prognostic Implications”. American Journal of Gastroenterology7 (2021): 1414-1425.
- Chai X., et al. “Specific Ace2 Expression in Cholangiocytes May Cause Liver Damage after 2019-Ncov Infection”. BioRxiv (2020).
- Hoffmann M., et al. “SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor”. Cell2 (2020): 271-280.e278.
- Zhao B., et al. “Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids”. Protein Cell10 (2020): 771-775.
- Scheppach W., et al. “Sclerosing cholangitis and liver cirrhosis after extrabiliary infections: report on three cases”. Critical Care Medicine 29 (2001): 438-441.
- Veerankutty FH., et al. “Post-COVID-19 cholangiopathy: Current understanding and management options”. World Journal of Gastrointestinal Surgery5 (2003): 788-798.
- Hunyady P., et al. “Secondary Sclerosing Cholangitis Following Coronavirus Disease 2019 (COVID-19): A Multicenter Retrospective Study”. Clinical Infectious Diseases 76 (2023): e179-e187.
- Lagana SM., et al. “Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data”. Modern Pathology11 (2020): 2147-2155
- Leonhardt S., et al. “Trigger mechanisms of secondary sclerosing cholangitis in critically ill patients”. Critical Care1 (2015): 131.
- Soldera J., et al. “Billiary casts in post-COVID-19 cholangiopathy”. Gastroenterology and Hepatology4 (2023): 319-320.
- Lee A., et al. “Liver transplantation for post-COVID-19 sclerosing cholangitis”. BMJ Case Reports CP. (2021): 14.
- Kulkarni AV., et al. “Post-COVID-19 Cholestasis: A Case Series and Review of Literature”. Journal of Clinical and Experimental Hepatology6 (2022): 1580-1590.
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