Acta Scientific Clinical Case Reports

EditorialVolume 4 Issue 6

Determination of ACE gene polymorphism among COVID-19 Patients as Predictive Marker of Increased Risk of Thrombosis

Mustafa Ibrahim Abbas1, Mai Shakir Mohammed1 and Khalid Abdelsamea Mohamedahmed1,2*

1Department of Hematology and Immunohematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan
2Department of Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan

*Corresponding Author: Khalid Abdelsamea Mohamedahmed, Department of Hematology and Department of Immunology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan.

Received: January 27, 2023; Published: May 01, 2023

The highly contagious new human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coagulopathies are now recognized as major causes of mortality. SARS-CoV-2 may be a highly prothrombotic virus that alters the coagulation cascade in unknown ways, causing a steady rise in D-dimer as the severity and extent of micro thrombosis rises [1].

Keywords: Angiotensin-Converting Enzyme (ACE); Thrombosis; COVID-19

Bibliography

  1. Mohammed MS and Mohamedahmed KA. “Heme Oxygenase-1 (HMOX1) Gene Polymorphisms as Predictive Markers of Increased Risk of Thrombosis among Patients with COVID-19”. GMJ 11 (2022): e2398.
  2. Holcomb D., et al. “Gene variants of coagulation related proteins that interact with SARS-CoV-2”. PLOS Computational Biology 3 (2021): e1008805.
  3. McFadyen JD., et al. “The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications”. Circulation Research4 (2020): 571-587.
  4. Li P., et al. “Factors Associated With Risk of Postdischarge Thrombosis in Patients With COVID-19”. JAMA Network Open11 (2021): e2135397.
  5. Calabrese C., et al. “ACE Gene I/D Polymorphism and Acute Pulmonary Embolism in COVID19 Pneumonia: A Potential Predisposing Role”. Frontiers in Medicine (Lausanne) 7 (2021): 631148.
  6. Mohamedahmed KA., et al. “Thrombocytopenia as diagnostic and prognostic biomarker for severity of COVID-19 infection”. Edorium Journal of Infectious Diseases 5 (2021): 100013I03KM2021.
  7. Gemmati D., et al. “COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?” International Journal of Molecular Sciences 10 (2022): 3474.
  8. Karakaş Çelik S., et al. “Polymorphisms of ACE (I/D) and ACE2 receptor gene (Rs2106809, Rs2285666) are not related to the clinical course of COVID-19: A case study”. Journal of Medical Virology10 (2021): 5947-5952.
  9. Gemmati D and Tisato V. “Genetic Hypothesis and Pharmacogenetics Side of Renin-Angiotensin-System in COVID-19”. Genes (Basel)9 (2020): 1044.
  10. Oscanoa TJ., et al. “ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a meta-analysis”. Arterial Hypertense3 (2012): 112-118.

Citation: Khalid Abdelsamea Mohamedahmed., et al. “Determination of ACE gene polymorphism among COVID-19 Patients as Predictive Marker of Increased Risk of Thrombosis". Acta Scientific Clinical Case Reports 4.6 (2023): 01-02.

Copyright: © 2023 Khalid Abdelsamea Mohamedahmed., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US