Mohammed Afzal*

Independent Researcher, Sweden

*Corresponding Author: Mohammed Afzal, Independent Researcher, Sweden.

Received: December 13, 2022; Published: January 10, 2023

Abstract

Background: The study explored the prevalence of biofilm formers in Klebsiella Pneumonia, a gram-negative bacterium that has high propensity to form antibiotic resistant strains and forms biofilms. Biofilms are complex microbial community with attributes that vary from planktonic cells.

Methods: A single-armed meta-analysis was done to assess prevalence of biofilm formers. Published studies were reviewed from PubMed and Scopus. A random effects meta-analysis was done. Freeman-Tuckey double arcsine method was selected for transformation. Publication bias was assessed using Doi plot and Luis Furuya-Kanamori (LFK) index.

Results: 23 studies were selected for the review. The meta-analysis revealed 74% (95% CI: 64%-83%) prevalence of biofilm formers among clinical isolates of Klebsiella pneumonia. The indices of heterogeneity among the included studies was high, indicated by a p value <0.01 and I² = 94.4%. Doi plot showed asymmetry marked by unequal deviation and lengths of the arms. The LFK index of -0.67.

Conclusions: The prevalence rate is comparable with that of prevalence rate attained by other bacterium by similar meta-analysis studies. This high prevalence of biofilm formers warrants for a paradigm shift in treatment strategies for treatment of infections.

Keywords: Biofilm; K. Pneumonia; Meta-analysis

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Citation: Mohammed Afzal. “The Prevalence of Biofilm Formers Among Clinical Isolates of Klebsiella pneumoniae: A Meta-Analysis". Acta Scientific Clinical Case Reports 4.2 (2023): 20-24.

Copyright: © 2022 Mohammed Afzal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.