The Prevalence of Biofilm Formers Among Clinical Isolates of Klebsiella pneumoniae: A Meta-Analysis
Mohammed Afzal*
Independent Researcher, Sweden
*Corresponding Author: Mohammed Afzal, Independent Researcher, Sweden.
Received: December 13, 2022;
Published: January 10, 2023
Abstract
Background: The study explored the prevalence of biofilm formers in Klebsiella Pneumonia, a gram-negative bacterium that has high propensity to form antibiotic resistant strains and forms biofilms. Biofilms are complex microbial community with attributes that vary from planktonic cells.
Methods: A single-armed meta-analysis was done to assess prevalence of biofilm formers. Published studies were reviewed from PubMed and Scopus. A random effects meta-analysis was done. Freeman-Tuckey double arcsine method was selected for transformation. Publication bias was assessed using Doi plot and Luis Furuya-Kanamori (LFK) index.
Results: 23 studies were selected for the review. The meta-analysis revealed 74% (95% CI: 64%-83%) prevalence of biofilm formers among clinical isolates of Klebsiella pneumonia. The indices of heterogeneity among the included studies was high, indicated by a p value <0.01 and I2 = 94.4%. Doi plot showed asymmetry marked by unequal deviation and lengths of the arms. The LFK index of -0.67.
Conclusions: The prevalence rate is comparable with that of prevalence rate attained by other bacterium by similar meta-analysis studies. This high prevalence of biofilm formers warrants for a paradigm shift in treatment strategies for treatment of infections.
Keywords: Biofilm; K. Pneumonia; Meta-analysis
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