Acta Scientific Clinical Case Reports

Case ReportVolume 4 Issue 1

Successful Treatment of Nonunion Following Periacetabular Osteotomy Using Teriparatide: A Case Report

Mackenzie Neumaier*, Jason Lipof and P Christopher Cook

Department of Orthopaedic Surgery, University of Rochester Medical Center, United States

*Corresponding Author: Mackenzie Neumaier, Department of Orthopaedic Surgery, University of Rochester Medical Center, United States.

Received: November 16, 2022; Published: December 30, 2022


Case: Two cases of osteotomy site nonunion after periacetabular osteotomy in healthy patients. Treatment with teriparatide (Forteo; Eli Lilly and Company, Indianapolis, IN) was initiated between 5-6 months post-operatively resulting in successful union, bony remodeling and symptom relief.

Conclusion: Teriparatide is a safe, effective and non-invasive means of aiding treatment of a relatively common complication following periacetabular osteotomy.

Keywords: Periacetabular Osteotomy (PAO); Parathyroid Hormone (PTH); Femoral-Acetabular Impingement (FAI)


  1. Ganz R., et al. “A New Periacetabular Osteotomy for Treatment of Hip Dysplasias. Technique and Preliminary Results”. Clinical Orthopaedics and Related Research 232 (1988): 26-36.
  2. Sanchez-Sotelo J., et al. “Surgical Treatment of Developmental Dysplasia in Adults: I. Nonarthroplasty Options”. Journal of American Academy of Orthopaedic Surgeons5 (2002): 321-333.
  3. Larsen J., et al. “14-year hip survivorship after periacetabular osteotomy: a follow-up study of 1,385 hips”. Acta Orthopaedica3 (2020): 299-305.
  4. Clohisy J., et al. “Periacetabular Osteotomy: A Systematic Literature Review”. Clinical Orthopaedics and Related Research 467 (2009): 2041-2052.
  5. Holleyman R., et al. “Periacetabular Osteotomy for Developmenta Dysplasia of the Hip and Femoroacetabular Impingement”. The Journal of Bone and Joint Surgery 102 (2020): 1312-1320.
  6. Cho Y., et al. “Long-Term Results of Periacetabular Rotational Osteotomy Concomitantly with Arthroscopy in Adult Acetabular Dysplasia”. The Journal of Arthroplasty 35 (2020): 2807-2812.
  7. Clohisy J., et al. “Patient-Reported Outcomes of Periacetabular Osteotomy from the Prospective ANCHOR Cohort Study”. The Journal of Bone and Joint Surgery 99 (2017): 33-41.
  8. Biedermann R., et al. “Complications and patient satisfaction after periacetabular pelvic osteotomy International Orthopaedics 32 (2008): 611-617.
  9. Selberg C., et al. “What Proportion of Patients Undergoing Bernese Periacetabular Osteotomy Experience Nonunion, and What Factors are Associated with Nonunion?” Clinical Orthopaedics and Related Research 478 (2020): 1648-1656.
  10. Wells J., et al. “Are Complications After there Bernese Periacetabular Osteotomy Associated with Subsequent Outcomes Scores?” Clinical Orthopaedics and Related Research 477 (2019): 1157-1163.
  11. Canintika A and Dilogo I. “Teriparatide for treating delayed union and nonunion: A systematic review”. Journal of Clinical Orthopadics and Trauma 11 (2020): S107-S112.
  12. Pietrogrande L and Raimondo E. “Teriparatide in the treatment of non-unions: Scientific and clinical evidences”. Injury 44 (2013): S54-S57.
  13. Lindsay R., et al. “Teriparatide for osteoporosis: The importance of the full course”. Osteoporosis International 27 (2017): 2395-2410.
  14. Quattrocchi E and Kourlas H. “Teriparatide: A Review”. Clinical Therapeutics6 (2004): 841-854.
  15. Bukata S and Puzas J. “Orthopedic Uses of Teriparatide”. Current Osteoporosis Reports 8 (2010): 28-33.
  16. Yoon B and Kim K. “Does Teriparatide Improve Fracture Union?: A Systematic Review”. Journal of Bone Metabolism3 (2020): 167-174.
  17. Giannotti S., et al. “Atrophic femoral nonunion successfully treated with teriparatide”. European Journal of Orthopaedic Surgery and Traumatology 23 (2013): S291-S294.
  18. Mitani Y. “Effective treatment of a steroid-induced femoral neck fracture nonunion with once-weekly administration of teriparatide in a rheumatoid patient: A case report”. Archives of Osteoporosis 8 (2013): 131-133.
  19. Oteo-Alvaro A and Moreno E. “Atrophyc humeral shaft nonunion treated with teriparatide: A case report”. Journal of Shoulder and Elbow Surgery 19 (2010): e22-e28.
  20. F Marin. “Treatment of Chronic Nonunion of a Sternal Fracture With Teriparatide”. Annals of Thoracic Surgery 111 (2021): e41-42.
  21. Rubery P and Bukata S. “Teriparatide May Accelerate Healing in Delayed Unions of Type III Odontoid Fractures: A Report of 3 Cases”. Journal of Spinal Disorders and Techniques 23 (2010): 151-155.
  22. Ramani A and Wagner R. “Periprosthetic Femoral Stress Fracture After Bisphosphonate Treatment Resulting in Nonunion Successfully Treated with Teriparatide”. JBJS Case Connect2 (2016): 1-5.
  23. Lipof J., et al. “Treatment of an Acromial Stress Fracture After Reverse Total Shoulder Arthroplasty With Teriparatide”. JBJS Case Connect2 (2020): 1-7.
  24. Lee H., et al. “Effects of teriparatide on fusion rates in patients undergoing complex foot and ankle arthrodesis”. Foot and Ankle Surgery 25 (2020): 766-770.
  25. Peichl P., et al. “Parathyroid Hormone 1-84 Accelerates Fracture-Healing in Pubic Bones of Elderly Osteoporotic Women”. The Journal of Bone and Joint Surgery 93 (2011): 1583-1587.
  26. Moon N., et al. “Effects of Teriparatide on Treatment Outcomes in Osteoporotic Hip and Pelvic Bone Fractures: Meta-analysis and Systematic Review of Randomized Controlled Trials”. Hip and Pelvis4 (2020): 182-191.

Citation: Mackenzie Neumaier., et al. “Successful Treatment of Nonunion Following Periacetabular Osteotomy Using Teriparatide: A Case Report". Acta Scientific Clinical Case Reports 4.1 (2023): 53-58.

Copyright: © 2022 Mackenzie Neumaier., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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