Roll of N-nitrosamines and Opium in Oesophageal Cancer
Orlando Téllez Almenares*
General Surgery Department, Saturnino Lora Provincial Hospital, Santiago de Cuba, Cuba
*Corresponding Author: Orlando Téllez Almenares, General Surgery Department, Saturnino Lora Provincial Hospital, Santiago de Cuba, Cuba.
Received: October 28, 2022;
Published: December 05, 2022
There are substances recognised as carcinogens for SCC, the main ones being nitrosamines or N-nitrosamines, which are potent carcinogens present in nature and result from the reaction of nitrites with primary, secondary, or tertiary amines in an acidic environment. The role of these compounds in the origin of different types of cancers in humans and animals has been reported for decades . Humans have been exposed to these carcinogens mainly through tobacco consumption, where more than 70% of nitrosamines have been identified. Compounds considered to be carcinogenically detected in tobacco are N-nitrosonornicotine (NNN), nitrosamine ketone-nicotine (NNK), N-nitrosoanabasine (NAB), and N-nitrosoanatabine derivative (NAT) [2,3].
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