Multiple System Atrophy in a Filipino 36-year-old Female Presenting as Progressive Gait Ataxia - A Case Report
Meleza Mea B Cambalon and Luis C Lagarde*
Graduate of Neurology in Philippines
*Corresponding Author: Luis C Lagarde, Graduate of Neurology in Philippines.
Received: August 01, 2022; Published: August 25, 2022
Abstract
Multiple system atrophy (MSA) is a rare, progressive, fatal, neurodegenerative disorder with incidence and prevalence of 0.6 to 0.7 cases per 100,000 and 3.4 to 4.9 cases per 100,000 population, respectively [1]. This is a case of a 36-year-old woman presenting with predominant features of gait ataxia. On imaging, there was marked cerebro-cerebellar atrophy more prominent in the cerebellum.
Keywords: Multiple system atrophy (MSA); Covid-19; Hypertension
- Fanciulli A and Wenning GK. “Multiple-system atrophy”. The New England Journal of Medicine 3 (2015): 249-263.
- Roncevic D., et al. “Cerebellar and parkinsonian phenotypes in multiple system atrophy: similarities, differences and survival”. Journal of Neural Transmission (Vienna) 121 (2014): 507-512.
- Quinn N. “A short clinical history of multiple system atrophy”. Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society 25 (2015): 3-7.
- Mendoza-Santiesteban CE., et al. “The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis”. Frontiers in Neurology 8 (2017a): 206.
- Palma JA., et al. “Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis”. Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society 25 (2015): 69-75.
- Petrovic IN., et al. “Multiple system atrophy-parkinsonism with slow progression and prolonged survival: a diagnostic catch”. Movement Disorders: Official Journal of the Movement Disorder Society 27 (2012): 1186-1190.
- Palma Jose-Alberto., et al. “Diagnosis of multiple system atrophy”. Autonomic Neuroscience: Basic and Clinical 211 (2018): 15-25.
- Lin DJ., et al. “Multiple system atrophy of the cerebellar type: clinical state of the art”. Movement Disorder 29 (2014): 294-304.
- Fanciulli Alessandra., et al. “Multiple System Atrophy”. International Review of Neurobiology 149 (2019): 137-192.
- Gilman S., et al. “Second consensus statement on the diagnosis of multiple system atrophy”. Neurology 71 (2008): 670-676.
- Singer Wolfgang., et al. “Alpha-Synuclein Oligomers and Neurofilament Light Chain in Spinal Fluid Differentiate Multiple System Atrophy from Lewy Body Synucleinopathies”. Annals of Neurology3 (2020): 503-512.