Acta Scientific Clinical Case Reports

Case ReportVolume 3 Issue 9

Suspected Parkinsonism Following COVID-19 Infection

Sam Kara1*, Reza S Roghani2, Pamela Youssef1 and Kester Nedd1

1Department of Neurology, Larkin Community Hospital Palm Springs Campus, Miami, Florida, USA
2Department of Physical Medicine and Rehabilitation, Larkin Community Hospital South Campus, Miami, Florida, USA

*Corresponding Author: Sam Kara, Department of Neurology, Larkin Community Hospital Palm Springs Campus, Miami, FL 33012, USA, samkara72@gmail.com

Received: August 01, 2022; Published: August 19, 2022

Abstract

Neurological complications, both acute and long- term, have been reported during the COVID-19 infection pandemic. Aside from idiopathic Parkinson's disease (PD), there are rare presentations of atypical parkinsonian syndromes. Infection, as an etiology, leading to PD or parkinsonism is rare. However, this hypothesis gained more traction as a result of the few cases reported during the COVID-19 pandemic. To date, less than a handful of reports describe parkinsonian type disease complications following COVID-19 infection. These cases, including this report, are important to establish the exact etiology and demographics (sex, age, and race) for this devastating COVID-19 sequelae. The COVID-19 virus was found to infiltrate and impact the central nervous system (CNS) through hematogenous and lymphatic routes, and through the cribriform plate via the olfactory bulb. These cases help to delineate the risk factors, improve our understanding of the duration and course of disease, treatment options, and solidify our knowledge of comorbidities affecting the presentation. We present a case of acute parkinsonism post-COVID-19 infection in an immunocompetent female. A brain Magnetic resonance imaging (MRI) revealed lesions in both the white matter and Globus palladium changes. All lesions had homogeneous contrast enhancement without any sign of hemorrhage, and affecting mostly the supratentorial punctiform and pontine areas. Patient symptoms improved on a trial of levodopa-carbidopa.

Keywords: Parkinson’s Disease; Parkinsonism; COVID-19; Tremor; Levodopa

Bibliography

  1. Collin Herman., et al. “Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19”. Neurology 2 (2020): 77-84.
  2. Abdul Mannan Baig., et al. “Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms”. ACS Chemical Neuroscience7 (2020): 995-998.
  3. Kara S., et al. “Evidence of post-COVID-19 transverse myelitis demyelination”. Cureus 10 (2021).
  4. Reem AlKetbi., et al. “Acute myelitis as a neurological complication of Covid-19: A case report and MRI findings”. Radiology Case Reports 15.9 (2020): 1591-1595.
  5. Ross W Paterson., et al. “The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings”. Brain10 (2020): 3104-3120.
  6. Morassi M., et al. “SARS-CoV-2-related encephalitis with prominent parkinsonism: clinical and FDG-PET correlates in two patients”. Journal of Neurology 268 (2021): 3980-3987.
  7. Cohen ME., et al. “A case of probable Parkinson’s disease after SARS-CoV-2 infection”. Lancet Neurology 19 (2020): 804-805.
  8. Méndez-Guerrero A., et al. “Acute hypokinetic-rigid syndrome following SARS-CoV-2 infection”. Neurology 95 (2020): e2109-e2118.
  9. Muhammad Durrani DO MS. "Infectious Acute Transverse Myelitis Secondary to COVID-19". REBEL EM blog, August 27, (2020).
  10. Coon EA and Singer W. “Synucleinopathies”. Continuum (Minneap Minn)1 (2020): 72-92.
  11. Kovacs GG. “Tauopathies”. Handbook of Clinical Neurology 145 (2017): 355-368.
  12. Keener AM and Bordelon YM. “Parkinsonism”. Seminar on Neurology4 (2016): 330-334.
  13. Sujan Poudel., et al. “Bell’s Palsy as a possible complication of mRNA-1273 (Moderna) vaccine against COVID-19”. Authorea (2022).
  14. Limphaibool N., et al. “Infectious etiologies of Parkinsonism: pathomechanisms and clinical implications”. Frontiers in Neurology 10 (2019): 652.
  15. Hoffman LA and Vilensky JA. “Encephalitis lethargica: 100 years after the epidemic”. Brain8 (2017): 2246-2251.

Citation: Sam Kara., et al. “Suspected Parkinsonism Following COVID-19 Infection". Acta Scientific Clinical Case Reports 3.9 (2022): 51-55.

Copyright: © 2022 Sam Kara., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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