Miller Fisher Syndrome and Acute Motor and Sensory Axonal Neuropathy (AMSAN) Variant Guillain-Barré Overlap Syndrome (MFS/AMSAN-GBS) After Upper Respiratory Tract Infection (URTI)
Tan Chun Chau* and Nik Azlan Nik Muhamad
Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Kuala Lumpur, Malaysia
*Corresponding Author: Tan Chun Chau, Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Kuala Lumpur, Malaysia.
Received: February 22, 2022; Published: June 02, 2022
A 50-year-old woman was admitted to the emergency room (ED) with progressive weakness and ascending numbness of the body, back pain, dysphagia, and diplopia for two days. The neurological findings were preceded by an upper respiratory tract infection. Subsequently, severe weakness of the bulbar and limb muscles, areflexia, and ophthalmoplegia developed. Based on clinical features, Miller-Fisher syndrome (MFS) was diagnosed, while a nerve conduction study revealed an overlap with acute motor-sensory axonal neuropathy (AMSAN) variant Guillain-Barré syndrome (MFS/AMSAN-GBS). The panel of anti-ganglioside antibodies was positive. Early treatment with intravenous immunoglobulin favored the outcome.
Keywords: Demyelinating Disease; Polyneuropathies; Guillain-Barré Syndrome; Miller Fisher Syndrome
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