Acta Scientific Clinical Case Reports

EditorialVolume 3 Issue 7

Senescent Tumor Cells: The Pacifism or Power Play of Tumor Aggression

Muhammad Imran1,2*

1Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, South Korea
2Inflammaging Translational Research Center, Ajou University School of Medicine, South Korea

*Corresponding Author: Muhammad Imran, 1Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, South Korea.

Received: March 23, 2022; Published: June 01, 2022

Cellular senescence is an irreversible cell cycle arrest caused by various internal or external stimuli [1,2]. Senescence phenotype was first identified by Hayflick in normal human fibroblasts [3]. Senescence is caused due to exhaustion of cells by continuous replication (replicative senescence) or it can be induced (induced senescence or premature senescence) by various agents including reactive oxygen species, tumor suppressors, oncogenes, radiations etc. Senescent cells are characterized by high accumulation of β-galactosidase, p16INK4A, p21Waf1, flattened cells morphology, reduced cells proliferation and also the release of senescence associated secretory phenotypes (SASPs), which comprise proinflammatory cytokines and chemokines, extracellular matrix proteins, growth factors, and exosome-like small extracellular vesicles [4-7].

Bibliography

  1. Park S S., et al. “Senescent tumor cells: an overlooked adversary in the battle against cancer”. Experimental and Molecular Medicine 53 (2021): 1834-1841.
  2. Park, J H., et al. “Disruption of nucleocytoplasmic trafficking as a cellular senescence driver”. Experimental and Molecular Medicine 53 (2021): 1092-1108.
  3. Hayflick L. “The limited in vitro lifetime of human diploid cell strains”. Experimental Cell Research 37 (1965): 614-636.
  4. Choi Y W., et al. “Senescent tumor cells build a cytokine shield in colorectal cancer”. Advanced Science4 (2021): 2002497.
  5. Kim Y H., et al. “Senescent tumor cells lead the collective invasion in thyroid cancer”. Nature Communication 8 (2017): 15208.
  6. Kim Y H., et al. “Cellular senescence in cancer”. BMB Reports 52 (2019): 42-46.
  7. Lee S., et al. “Cellular senescence: a promising strategy for cancer therapy”. BMB Reports 52 (2019): 35-41.
  8. Campisi J. “Aging, Cellular senescence, and cancer”. Annual Review of Physiology75 (2013): 685-705.
  9. Milanovic M. et al. “Senescence-associated reprogramming promotes cancer stemness”. Nature 553 (2018): 96-100.

Citation: Muhammad Imran. “Senescent Tumor Cells: The Pacifism or Power Play of Tumor Aggression". Acta Scientific Clinical Case Reports 3.7 (2022): 01-02.

Copyright: © 2022 Muhammad Imran. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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