Acta Scientific Clinical Case Reports

Research ArticleVolume 3 Issue 5

Epidemiology and Trend of Oesophageal Cancer in Santiago de Cuba

Téllez-Almenares O*, Cisneros-Domínguez CM and Romero-García LI

Department of General Surgery, Saturnino Lora Provincial Hospital, University of Medical Sciences of Santiago de Cuba, Cuba

*Corresponding Author: Téllez-Almenares O, Department of General Surgery, Saturnino Lora Provincial Hospital, University of Medical Sciences of Santiago de Cuba, Cuba.

Received: February 25, 2022; Published: April 19, 2022

Abstract

The incidence of oesophageal cancer varies significantly among different regions of the world and even within countries. More than 600 000 patients are diagnosed with oesophageal cancer worldwide each year. The aim of this research is to describe the epidemiological characteristics in the reference population and to identify the differential magnitude of incidence of patients with oesophageal cancer in the population, according to histological type. An observational, descriptive and cross-sectional study was conducted out in a first methodological stage and longitudinal one in a second(trend). For the analysis of the problems detected, the time period was from January 2011 to December 2020, and a sample of 197 patients was selected for the trend analysis. For the characterisation of the referred population, according to variables of interest, a subsample of 195 patients discharged from the hospital was selected, which included only the histological types of interest for the study: oesophageal adenocarcinoma and squamous cell carcinoma. Squamous cell carcinoma reported the highest percentages: 78.2%, but despite this, there was a slightly downward trend for this histological type and a slightly upward trend for oesophageal adenocarcinoma. The municipality of Santiago de Cuba registered the highest figures for both adenocarcinoma and squamous cell carcinoma: 40.3% and 26.8% respectively, with the highest number of cases in San Luis. The incidence of the disease was higher in patients over 50 years of age, with a high incidence in males and mixed race patients, although there were reports of subjects younger than 40 years old. The joint effect of tobacco and alcohol consumption showed a strong association for the development of oesophageal adenocarcinoma, with a Cramer's coefficient of 0.67.

Keywords: oesophageal adenocarcinoma, oesophagus cancer, squamous cell cancer

Bibliography

  1. Cancer figures in Spain. SEOM - World Cancer Day (2020).
  2. Cancer statistics - National Cancer Institute (2015).
  3. Short M., et al. “Esophageal Cancer”. American Family Physician 1 (2017): 22-28.
  4. Esophageal cancer - SEOM: Spanish Society of Medical Oncology© 2019 (2021).
  5. GBD 2017 Oesophageal Cancer Collaborators. “The global, regional, and national burden of oesophageal cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017”. The Lancet Gastroenterology and Hepatology 6 (2020): 582-597.
  6. Carballosa Espinosa L., et al. “Oesophageal cancer”. A 20-year study of intervened cases with resectable lesions”. Scientific Information Journal2 (2008): 11.
  7. Global Cancer Observatory. Oesophagus. Globocan (2020).
  8. Santell Odio FB., et al. “Cancer of the oesophagus”. In: Soler Vaillant R, Mederos Curbelo ON Surgery”. Havana, Cuba: Editorial de Ciencias Médicas (2018): 643-683.
  9. Castellanos González JA., et al. “Characterization of patients operated for esophageal cancer in Cuba”. Cuban Journal of Surgery4 (2021).
  10. Mingol Navarro F., et al. “Esophageal cancer”. Classification. Predisposing factors. Diagnosis and staging. In: Ortíz Escandell A, Martínez de Haro L, Parrilla Paricio P, editors. Esophagogastric surgery. Clinical Guides of the Spanish Association of Surgeons. Second Edition. Madrid, Spain: ARÁN Ediciones, S.L (2017): 237-251.
  11. Bedenne L., et al. “Esophageal cancer”. EMC - A Treatise on Medicine 4 (2017): 1-7.
  12. Pedram A., et al. “Esophageal cancer in northwestern Iran”. Indian Journal of Cancer2 (2011): 165.
  13. El Lakis M and Low DE. “Esophageal Cancer Diagnosis and Staging. En: Sabiston textbook of surgery the biological basis of modern surgical practice. 20th Estados Unidos: Elsevier (2017): 368-381.
  14. Locke G., et al. “Changes in the site- and histology-specific incidence of gastric cancer during a 50-year period”. Gastroenterology6 (1995): 1750-1756.
  15. Romera Garrido PL. “Epidemiology of oesophageal cancer in public hospitals in the Autonomous Community of Madrid: survival analysis (2011).
  16. Gallegos Plaza J. “Oesophageal cancer”. SEOM Spanish Society of Medical Oncology (2020).
  17. Nguyen M. “Oesophageal cancer”. MSD Manual Version for Professionals (2019).
  18. Gómez-Urrutia JM., et al. “Epidemiology of esophageal cancer in Hospital Juárez de México”. Endoscopy 1 (2017): 11-115.
  19. American Cancer Society. “Important statistics about esophageal cancer”. Cancer (2021).
  20. Cora Estopiñán S., et al. “Clinicopathological characterization of advanced esophageal cancer at the Comandante Faustino Pérez University Hospital. Matanzas”. Revista Médica Electrónica2 (2019): 15.
  21. Herrera MH., et al. “Characterization of esophageal cancer in operated patients. Hospital "Dr. Carlos J. Finlay". Habanera Journal of Medical Sciences1 (2014): 101-110.
  22. Nazario Dolz AM., et al. “Characterization of patients with esophageal cancer in the 2013-2014 biennium”. Medicine 2 (2016): 11.
  23. Ministry of Public Health. Anuario Estadístico de Salud 2020. Havana, Cuba: MINSAP/PAHO/WHO (2021).
  24. Codipilly DC., et al. “Epidemiology and outcomes of young-onset esophageal adenocarcinoma: an analysis from a population-based database”. Cancer Epidemiology, Biomarkers and Prevention 2021;30.1 (2021): 142-149.
  25. Alema ON and Iva B. “Cancer of the esophagus: histopathological sub-types in northern Uganda”. African Health Sciences 14.1 (2014): 17-21.
  26. Chen R., et al. “Analysis of incidence and mortality of esophageal cancer in China, 2015”. Zhonghua Yu Fang Yi Xue Za Zhi11 (2019): 1094-1097.
  27. Rafiemanesh H., et al. “Cancer epidemiology and trends in Sistan and Baluchestan province, Iran”. Medical Journal of The Islamic Republic of Iran 29 (2015):
  28. Ghadirian P. “Thermal irritation and esophageal cancer in northern Iran”. Cancer8 (1987): 1909-1914.
  29. Cattelan L., et al. “Epidemiologic trends and geographic distribution of esophageal cancer in Canada: A national population-based study”. Cancer Medicine1 (2020): 401-417.
  30. Laszkowska M., et al. “Racial and ethnic disparities in mortality from gastric and esophageal adenocarcinoma”. Cancer Medicine15 (2020): 5678-5686.
  31. Ashktorab H., et al. “Racial disparity in gastrointestinal cancer risk”. Gastroenterology4 (2017): 910-923.
  32. National Bureau of Statistics and Information. National Report - Population and Housing Census. Cuba 2012. Havana, Cuba: National Bureau of Statistics and Information (2013).
  33. San Luis Municipal Statistical Yearbook 2018. San Luis, Santiago de Cuba: National Office of Statistics and Information”. Republic of Cuba (2019).
  34. Luo Q., et al. “Spatial, temporal variability and carcinogenic health risk assessment of nitrosamines in a drinking water system in China”. Science of the Total Environment 736 (2020): 139695.
  35. Li X., et al. “Intake of volatile nitrosamines by Chinese residents in different provinces via food and drinking water”. Science of the Total Environment 754 (2021): 142121.
  36. Zhao C., et al. “Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai’an, China”. Chemosphere 235 (2019): 88-96.
  37. Dong J and Thrift AP. “Alcohol, smoking and risk of oesophago-gastric cancer”. Best Practice and Research: Clinical Gastroenterology 5 (2017): 509-517.
  38. WHO Framework Convention on Tobacco Control. Compendium of indicators (1st edition) (2015).
  39. Steevens J., et al. “Alcohol consumption, cigarette smoking and risk of subtypes of oesophageal and gastric cancer: a prospective cohort study”. Gut 1 (2010): 39-48.
  40. Abnet CC., et al. “Epidemiology of esophageal squamous cell carcinoma”. Gastroenterology2 (2018): 360-373.
  41. Wu M., et al. “Association of smoking, alcohol drinking and dietary factors with esophageal cancer in high- and low-risk areas of Jiangsu Province, China”. World Journal of Gastroenterology 11 (2006): 1686-1693.
  42. Hernández Almeida E. “Clinical course and prognostic factors of epidemic neuropathy. Thesis presented in option to the scientific degree of Doctor of Medical Sciences. Higher Institute of Medical Sciences of Santiago de Cuba”. Faculty of Medical Sciences of Manzanillo (2005).
  43. Matejcic M., et al. “Alcohol metabolism and oesophageal cancer: a systematic review of the evidence”. Carcinogenesis9 (2017): 859-872.
  44. Arango Flórez A. “Esophageal cancer”. Electronic Journal of Medical Portals 19 (2020): 987.
  45. Yang X., et al. “Smoking and alcohol drinking in relation to the risk of esophageal squamous cell carcinoma: A population-based case-control study in China”. Scientific Reports1 (2017): 17249.
  46. Lin Y., et al. “Epidemiology of esophageal cancer in Japan and China”. Journal of Epidemiology 4 (2013): 233-242.
  47. Bane A., et al. “Pattern of upper gastrointestinal tumors at Tikur Anbessa Teaching Hospital in Addis Ababa, Ethiopia: a ten-year review”. Ethiopian Medical Journal 1 (2009): 33-38.
  48. Patel JA., et al. “Nasopharyngeal Acute Phase Cytokines in Viral Upper Respiratory Infection: Impact on Acute Otitis Media in Children”. The Pediatric Infectious Disease Journal 11 (2009): 1002-1007.
  49. Wondimagegnehu A., et al. “Oesophageal cancer magnitude and presentation in Ethiopia 2012-2017”. PLOS ONE12 (2020): e0242807.
  50. Taruselli R and Santiago P. “Cáncer de esófago”. Clin Quir Fac Med UdelaR (2018).
  51. van Nistelrooij AMJ., et al. “Germline variant in MSX1 identified in a Dutch family with clustering of Barrett’s esophagus and esophageal adenocarcinoma”. Familial Cancer 3 (2018): 435-440.
  52. Coleman HG., et al. “The epidemiology of esophageal adenocarcinoma”. Gastroenterology2 (2018): 390-405.
  53. Edgren G., et al. “A global assessment of the oesophageal adenocarcinoma epidemic”. Gut10 (2013): 1406-1414.

Citation: Téllez-Almenares O., et al. “Epidemiology and Trend of Oesophageal Cancer in Santiago de Cuba". Acta Scientific Clinical Case Reports 3.5 (2022): 56-65.

Copyright: © 2022 Téllez-Almenares O., et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US